Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:19771621" >
C-peptide improves ...
C-peptide improves adenosine-induced myocardial vasodilation in type 1 diabetes patients
-
Johansson, BL (författare)
-
Sundell, J (författare)
-
Ekberg, K (författare)
-
visa fler...
-
Jonsson, C (författare)
-
Seppanen, M (författare)
-
Raitakari, O (författare)
-
Luotolahti, M (författare)
-
Nuutila, P (författare)
-
- Wahren, J (författare)
- Karolinska Institutet
-
Knuuti, J (författare)
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2004
- 2004
- Engelska.
-
Ingår i: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 286:1, s. E14-E19
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Patients with type 1 (insulin-dependent) diabetes show reduced skeletal muscle blood flow and coronary vasodilatory function despite intensive insulin therapy and good metabolic control. Administration of proinsulin C-peptide increases skeletal muscle blood flow in these patients, but a possible influence of C-peptide on myocardial vasodilatory function in type 1 diabetes has not been investigated. Ten otherwise healthy young male type 1 diabetic patients (Hb A1c 6.6%, range 5.7-7.9%) were studied on two consecutive days during normoinsulinemia and euglycemia in a double-blind, randomized, crossover design, receiving intravenous infusion of C-peptide (5 pmol·kg-1·min-1) for 120 min on one day and saline infusion on the other day. Myocardial blood flow (MBF) was measured at rest and during adenosine administration (140 μg·kg-1·min-1) both before and during the C-peptide or saline infusions by use of positron emission tomography and [15O]H2O administration. Basal MBF was not significantly different in the patients compared with an age-matched control group, but adenosine-induced myocardial vasodilation was 30% lower ( P < 0.05) in the patients. During C-peptide administration, adenosine-stimulated MBF increased on average 35% more than during saline infusion ( P < 0.02) and reached values similar to those for the healthy controls. Moreover, as evaluated from transthoracal echocardiographic measurements, C-peptide infusion resulted in significant increases in both left ventricular ejection fraction (+5%, P < 0.05) and stroke volume (+7%, P < 0.05). It is concluded that short-term C-peptide infusion in physiological amounts increases the hyperemic MBF and left-ventricular function in type 1 diabetic patients.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Johansson, BL
-
Sundell, J
-
Ekberg, K
-
Jonsson, C
-
Seppanen, M
-
Raitakari, O
-
visa fler...
-
Luotolahti, M
-
Nuutila, P
-
Wahren, J
-
Knuuti, J
-
visa färre...
- Artiklar i publikationen
-
American journal ...
- Av lärosätet
-
Karolinska Institutet