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aMMP-8 Oral Fluid P...
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Sorsa, TKarolinska Institutet
(författare)
aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-06-10
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Frontiers Media SA,2022
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:235757444
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http://kipublications.ki.se/Default.aspx?queryparsed=id:235757444URI
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https://doi.org/10.3389/froh.2022.897115DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75–85% and specificity in the range of 80–90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nwhator, SO
(författare)
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Sakellari, D
(författare)
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Grigoriadis, A
(författare)
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Umeizudike, KA
(författare)
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Brandt, E
(författare)
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Keskin, M
(författare)
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Tervahartiala, T
(författare)
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Pärnänen, P
(författare)
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Gupta, S
(författare)
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Mohindra, R
(författare)
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Bostanci, NKarolinska Institutet
(författare)
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Buduneli, N
(författare)
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Räisänen, IT
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Frontiers in oral health: Frontiers Media SA3, s. 897115-2673-4842
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- Av författaren/redakt...
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Sorsa, T
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Nwhator, SO
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Sakellari, D
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Grigoriadis, A
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Umeizudike, KA
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Brandt, E
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visa fler...
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Keskin, M
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Tervahartiala, T
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Pärnänen, P
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Gupta, S
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Mohindra, R
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Bostanci, N
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Buduneli, N
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Räisänen, IT
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Karolinska Institutet