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Association between...
Association between brain volume and disability over time in multiple sclerosis
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- Moridi, T (författare)
- Karolinska Institutet
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- Stawiarz, L (författare)
- Karolinska Institutet
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- McKay, KA (författare)
- Karolinska Institutet
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Ineichen, BV (författare)
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- Ouellette, R (författare)
- Karolinska Institutet
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- Ferreira, D (författare)
- Karolinska Institutet
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- Muehlboeck, JS (författare)
- Karolinska Institutet
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- Westman, E (författare)
- Karolinska Institutet
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- Kockum, I (författare)
- Karolinska Institutet
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- Olsson, T (författare)
- Karolinska Institutet
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Piehl, F (författare)
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- Hillert, J (författare)
- Karolinska Institutet
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- Manouchehrinia, A (författare)
- Karolinska Institutet
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- Granberg, T (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-12-18
- 2022
- Engelska.
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Ingår i: Multiple sclerosis journal - experimental, translational and clinical. - : SAGE Publications. - 2055-2173. ; 8:4, s. 20552173221144230-
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Most previous multiple sclerosis (MS) brain atrophy studies using MS impact scale 29 (MSIS-29) or symbol digit modalities test (SDMT) have been cross-sectional with limited sets of clinical outcomes. Objectives To investigate which brain and lesion volume metrics show the strongest long-term associations with the expanded disability status scale (EDSS), SDMT, and MSIS-29, and whether MRI-clinical associations vary with age. Methods We acquired MRI and clinical data from a real-world Swedish MS cohort. FreeSurfer and SPM Lesion Segmentation Tool were used to obtain brain parenchymal, cortical and subcortical grey matter, thalamic and white matter fractions as well as T1- and T2-lesion volumes. Mixed-effects and rolling regression models were used in the statistical analyses. Results We included 989 persons with MS followed for a median of 9.3 (EDSS), 10.1 (SDMT), and 9.3 (MSIS-29) years, respectively. In a cross-sectional analysis, the strength of the associations of the MRI metrics with the EDSS and MSIS-29 was found to drastically increase after 40–50 years of age. Low baseline regional grey matter fractions were associated with longitudinal increase of EDSS and physical MSIS-29 scores and decrease in SDMT scores and these atrophy measures were stronger predictors than the lesion volumes. Conclusions The strength of MRI-clinical associations increase with age. Grey matter volume fractions are stronger predictors of long-term disability measures than lesion volumes.
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Moridi, T
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Stawiarz, L
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McKay, KA
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Ineichen, BV
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Ouellette, R
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Ferreira, D
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visa fler...
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Muehlboeck, JS
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Westman, E
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Kockum, I
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Olsson, T
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Piehl, F
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Hillert, J
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Manouchehrinia, ...
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Granberg, T
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visa färre...
- Artiklar i publikationen
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Multiple scleros ...
- Av lärosätet
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Karolinska Institutet