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Associations between inflammatory and angiogenic proteomic biomarkers, and cardiovascular events and mortality in relation to kidney function
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- Salzinger, Barbara (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Nephrol, Stockholm, Sweden.
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- Lundwall, Kristina (författare)
- Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden
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- Evans, Marie (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Intervent & Technol, ME Renal Med, Stockholm, Sweden.
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- Mörtberg, Josefin (författare)
- Uppsala University,Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Wallen, Håkan (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden.
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- Jernberg, Tomas (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden.
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- Kahan, Thomas (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden.
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- Lundman, Pia (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden.
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- Tornvall, Per (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden.
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- Lindahl, Bertil, 1957- (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Baron, Tomasz (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Rezeli, Melinda (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Forskargrupper vid Lunds universitet,Clinical Protein Science and Imaging,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Dept Biomed Engn, Clin Prot Sci & Imaging, Lund, Sweden.
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- Spaak, Jonas (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden.
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- Jacobson, Stefan H. (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Nephrol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Div Nephrol, Stockholm, Sweden (creator_code:org_t)
- Oxford University Press, 2024
- 2024
- Engelska.
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Ingår i: Clinical Kidney Journal. - : Oxford University Press. - 2048-8505 .- 2048-8513. ; 17:3
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Abstract
Ämnesord
Stäng
- BackgroundThe links between chronic kidney disease (CKD) and the high burden of cardiovascular disease remain unclear. We aimed to explore the association between selected inflammatory and angiogenic biomarkers, kidney function and long-term outcome in patients with an acute coronary syndrome (ACS) and to test the hypothesis that CKD status modifies this association.MethodsA total of 1293 ACS patients hospitalized between 2008 and 2015 were followed until 31 December 2017. Plasma was collected on days 1–3 after admission. A total of 13 biomarkers were a priori identified and analysed with two proteomic methods, proximity extension assay or multiple reaction monitoring mass spectrometry. Boxplots and multiple linear regression models were used to study associations between biomarkers and kidney function and adjusted standardized Cox regression with an interaction term for CKD was used to assess whether CKD modified the association between biomarkers and major adverse cardiovascular events and death (MACE+).ResultsThe concentrations of nine biomarkers—endothelial cell-specific molecule-1 (ESM-1), fibroblast growth factor 23 (FGF-23), fractalkine (CX3CL1), interleukin-1 receptor antagonist (IL-1RA), interleukin-18 (IL-18), monocyte chemotactic protein-1 (MCP-1), placenta growth factor (PlGF), transmembrane immunoglobulin 1 (TIM-1) and vascular endothelial growth factor A (VEGFA)—were inversely associated with kidney function. ESM-1, FGF-23 and TIM-1 showed associations with MACE+. Only FGF23 remained independently associated after adjustment for the other biomarkers (hazard ratio per standard deviation increase 1.34; 95% Bonferroni corrected confidence interval 1.19–1.50). None of the biomarkers showed an interaction with CKD.ConclusionsThe concentrations of 9 of the 13 prespecified inflammatory and angiogenic proteomic biomarkers increased when kidney function declined. Only FGF-23 demonstrated an independent association with MACE+, and this association was not modified by CKD status. These findings further support FGF-23 as an independent prognostic marker in ACS patients with and without CKD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- ACS
- biomarkers
- kidney function
- prognosis
- ACS
- biomarkers
- kidney function
- prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Salzinger, Barba ...
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Lundwall, Kristi ...
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Evans, Marie
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Mörtberg, Josefi ...
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Wallen, Håkan
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Jernberg, Tomas
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Kahan, Thomas
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Lundman, Pia
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Tornvall, Per
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Erlinge, David
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Lindahl, Bertil, ...
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Baron, Tomasz
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Rezeli, Melinda
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Spaak, Jonas
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Jacobson, Stefan ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Clinical Kidney ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet