SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-228688"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-228688" > Genetic contributio...

Genetic contribution to disease-course severity and progression in the SUPER-Finland study, a cohort of 10,403 individuals with psychotic disorders

Kämpe, Anders (författare)
Karolinska Institutet,Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Molecular Medicine and surgery (MMK), Karolinska Institutet, Stockholm, Sweden
Suvisaari, Jaana (författare)
National Institute for Health and Welfare, Department of Mental Health and Substance Abuse Services, Helsinki, Finland
Lahteenvuo, Markku (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Department of Forensic Psychiatry, University of Eastern Finland School of Medicine, Niuvanniemi hospital, Kuopio, Finland
visa fler...
Singh, Tarjinder (författare)
Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA, USA; Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA
Ahola-Olli, Ari (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Urpa, Lea (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Haaki, Willehard (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Hietala, Jarmo (författare)
Department of Psychiatry, University of Turku, Turku, Finland
Isometsa, Erkki (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Jukuri, Tuomas (författare)
Department of Psychiatry, Oulu University Hospital, Oulu, Finland
Kampman, Olli (författare)
Umeå universitet,Psykiatri,Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Psychiatry, The Wellbeing Services County of Ostrobothnia, Ostrobothnia, Finland; Department of Clinical Medicine (Psychiatry), Faculty of Medicine, University of Turku, Turku, Finland
Kieseppa, Tuula (författare)
Hospital District of Helsinki and Uusimaa, Helsinki, Finland
Lahdensuo, Kaisla (författare)
University of Helsinki, Helsinki, FinlandUniversity of Helsinki, Helsinki, Finland
Lönnqvist, Jouko (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland
Mannynsalo, Teemu (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Paunio, Tiina (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; National Institute for Health and Welfare, Helsinki, Finland; SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Niemi-Pynttari, Jussi (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Suokas, Kimmo (författare)
Tampere University, Tampere, Finland; Department of Psychiatry, Tampere University Hospital, Tampere, Finland
Tuulio-Henriksson, Annamari (författare)
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Veijola, Juha (författare)
Department of Psychiatry, Oulu University Hospital, Oulu, Finland; Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland
Wegelius, Asko (författare)
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Daly, Mark (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA, USA; Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA; Broad Institute Harvard, Program in Medical and Population Genetics, Cambridge, MA, USA
Taylor, Jacob (författare)
Harvard Medical School, Department of Medicine, Boston, USA
Kendler, Kenneth S. (författare)
Virginia Institute of Psychiatric and Behavioral Genetics, Richmond, VA, USA; Medical College of Virginia/Virginia Commonwealth University, Department of Psychiatry, Richmond, VA, USA
Palotie, Aarno (författare)
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA, USA
Pietilainen, Olli (författare)
Broad Institute, Stanley Center for Psychiatric Research, Cambridge, MA, USA; Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland
visa färre...
 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Molecular Psychiatry. - : Springer Nature. - 1359-4184 .- 1476-5578.
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Genetic factors contribute to the susceptibility of psychotic disorders, but less is known how they affect psychotic disease-course development. Utilizing polygenic scores (PGSs) in combination with longitudinal healthcare data with decades of follow-up we investigated the contributing genetics to psychotic disease-course severity and diagnostic shifts in the SUPER-Finland study, encompassing 10 403 genotyped individuals with a psychotic disorder. To longitudinally track the study participants' past disease-course severity, we created a psychiatric hospitalization burden metric using the full-coverage and nation-wide Finnish in-hospital registry (data from 1969 and onwards). Using a hierarchical model, ranking the psychotic diagnoses according to clinical severity, we show that high schizophrenia PGS (SZ-PGS) was associated with progression from lower ranked psychotic disorders to schizophrenia (OR = 1.32 [1.23-1.43], p = 1.26e-12). This development manifested already at psychotic illness onset as a higher psychiatric hospitalization burden, the proxy for disease-course severity. In schizophrenia (n = 5 479), both a high SZ-PGS and a low educational attainment PGS (EA-PGS) were associated with increased psychiatric hospitalization burden (p = 1.00e-04 and p = 4.53e-10). The SZ-PGS and the EA-PGS associated with distinct patterns of hospital usage. In individuals with high SZ-PGS, the increased hospitalization burden was composed of longer individual hospital stays, while low EA-PGS associated with shorter but more frequent hospital visits. The negative effect of a low EA-PGS was found to be partly mediated via substance use disorder, a major risk factor for hospitalizations. In conclusion, we show that high SZ-PGS and low EA-PGS both impacted psychotic disease-course development negatively but resulted in different disease-course trajectories.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy