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Effects of a long-t...
Effects of a long-term lifestyle intervention on metabolically healthy women with obesity: Metabolite profiles according to weight loss response
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- Palau-Rodriguez, Magali (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII),Universitat de Barcelona,University of Barcelona
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- Garcia-Aloy, Mar (författare)
- Universitat de Barcelona,University of Barcelona
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- Miñarro, Antonio (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII),Universitat de Barcelona,University of Barcelona
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- Bernal-Lopez, M. Rosa (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII)
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- Brunius, Carl, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gómez-Huelgas, Ricardo (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII)
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- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Tinahones, Francisco J. (författare)
- Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII)
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- Andres-Lacueva, Cristina (författare)
- Universitat de Barcelona,University of Barcelona,Instituto de Salud Carlos III (ISCIII),Institute of Health Carlos III (ISCIII)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Clinical Nutrition. - : Elsevier BV. - 1532-1983 .- 0261-5614. ; 39:1, s. 215-224
- Relaterad länk:
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http://diposit.ub.ed...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background & aims: The benefits of weight loss in subjects with metabolically healthy obesity (MHO) are still a matter of controversy. We aimed to identify metabolic fingerprints and their associated pathways that discriminate women with MHO with high or low weight loss response after a lifestyle intervention, based on a hypocaloric Mediterranean diet (MedDiet) and physical activity. Methods: A UPLC-Q-Exactive-MS/MS metabolomics workflow was applied to plasma samples from 27 women with MHO before and after 12 months of a hypocaloric weight loss intervention with a MedDiet and increased physical activity. The subjects were stratified into two age-matched groups according to weight loss: <10% (low weight loss group, LWL) and >10% (high weight loss group, HWL). Random forest analysis was performed to identify metabolites discriminating between the LWL and the HWL as well as within-status effects. Modulated pathways and associations between metabolites and anthropometric and biochemical variables were also investigated. Results: Thirteen metabolites discriminated between the LWL and the HWL, including 1,5-anhydroglucitol, carotenediol, 3-(4-hydroxyphenyl)lactic acid, N-acetylaspartate and several lipid species (steroids, a plasmalogen, sphingomyelins, a bile acid and long-chain acylcarnitines). 1,5-anhydroglucitol, 3-(4-hydroxyphenyl)lactic acid and sphingomyelins were positively associated with weight variables whereas N-acetylaspartate and the plasmalogen correlated negatively with them. Changes in very long-chain acylcarnitines and hydroxyphenyllactic levels were observed in the HWL and positively correlated with fasting glucose, and changes in levels of the plasmalogen negatively correlated with insulin resistance. Additionally, the cholesterol profile was positively associated with changes in acid hydroxyphenyllactic, sphingolipids and 1,5-AG. Conclusions: Higher weight loss after a hypocaloric MedDiet and increased physical activity for 12 months is associated with changes in the plasma metabolome in women with MHO. These findings are associated with changes in biochemical variables and may suggest an improvement of the cardiometabolic risk profile in those patients that lose greater weight. Further studies are needed to investigate whether the response of those subjects with MHO to this intervention differs from those with unhealthy obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- LC-MS
- Lifestyle intervention
- Obesity
- Mediterranean diet
- Metabolically healthy obese
- Metabolomics
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Palau-Rodriguez, ...
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Garcia-Aloy, Mar
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Miñarro, Antonio
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Bernal-Lopez, M. ...
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Brunius, Carl, 1 ...
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Gómez-Huelgas, R ...
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Landberg, Rikard ...
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Tinahones, Franc ...
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Andres-Lacueva, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Annan klinisk me ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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Clinical Nutriti ...
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Chalmers tekniska högskola