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Human protein secre...
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Feizi, Amir,1980Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.
(författare)
Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-08-18
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Springer Science and Business Media LLC,2017
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:01872eaf-7f6b-40ef-85cc-7aaa60b9300a
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https://doi.org/10.1038/s41540-017-0021-4DOI
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https://research.chalmers.se/publication/504895URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-271108URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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QC 20200317
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Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to cancer. Despite the piled-up knowledge on the molecular biology and biochemistry level, the tissue-specific expression of the secretory pathway genes has not been analyzed on the transcriptome level. Based on the recent RNA-sequencing studies, the largest fraction of tissue-specific transcriptome encodes for the secretome (secretory proteins). Here, the question arises that if the expression levels of the secretory pathway genes have a tissue-specific tuning. In this study, we tackled this question by performing a meta-analysis of the recently published transcriptome data on human tissues. As a result, we detected 68 as called “extreme genes” which show an unusual expression pattern in specific gene families of the secretory pathway. We also inspected the potential functional link between detected extreme genes and the corresponding tissues enriched secretome. As a result, the detected extreme genes showed correlation with the enrichment of the nature and number of specific post-translational modifications in each tissue’s secretome. Our findings conciliate both the housekeeping and tissue-specific nature of the protein secretory pathway, which we attribute to a fine-tuned regulation of defined gene families to support the diversity of secreted proteins and their modifications.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gatto, Francesco,1987KTH,Science for Life Laboratory, SciLifeLab,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.(Swepub:kth)u13spkod
(författare)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2970 Horsholm, Denmark.(Swepub:kth)u1dulvmw
(författare)
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Nielsen, Jens B,1962Danmarks Tekniske Universitet,Technical University of Denmark,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2970 Horsholm, Denmark.;Royal Inst Technol, Sci Life Lab, SE-17121 Stockholm, Sweden.(Swepub:kth)u1avl7k2
(författare)
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Chalmers tekniska högskolaChalmers Univ Technol, Dept Biol & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.;Chalmers Univ Technol, Novo Nordisk Fdn Ctr Biosustainabil, SE-41296 Gothenburg, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:npj Systems Biology and Applications: Springer Science and Business Media LLC3:12056-7189
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