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Design and biofabri...
Design and biofabrication of a leaf-inspired vascularized cell-delivery device
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- Sämfors, Sanna, 1987 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Niemi, Essi M. (författare)
- Universitetet i Oslo,University of Oslo,Oslo universitetssykehus,Oslo University Hospital
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- Oskarsdotter, Kristin (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Egea, Claudia Villar (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mark, Andreas, 1980 (författare)
- Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC),Fraunhofer-Chalmers Research Centre for Industrial Mathematics (FCC)
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- Scholz, Hanne (författare)
- Oslo universitetssykehus,Oslo University Hospital,Universitetet i Oslo,University of Oslo
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- Gatenholm, Paul, 1956 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Bioprinting. - : Elsevier BV. - 2405-8866. ; 26
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We designed and biofabricated a channeled construct as a possible cell-delivery device that can be endothelialized to overcome size limitations due to oxygen diffusion. The channeled device mimicking a leaf was designed using computer-aided design software, with fluid flow through the channels visualized using simulation studies. The device was fabricated either by form casting using a custom 3D-printed plastic mold or by 3D-bioprinting using Pluronic F-127 as sacrificial ink to print the channels. The actual leaf was cast or bioprinted using hydrogel made from a mixture of tunicate cellulose nanofibers and alginate that was cross-linked in calcium chloride solution to allow a stable device. The resulting device was a 20 × 8 × 3 mm or 35 × 18 × 3 mm (length × width × height) leaf with one main channel connected to several side channels. Surface modification using periodate oxidation, followed by laminin bioconjugation, was performed to enhance endothelial cell adhesion in the channels. We subsequently used human umbilical vein endothelial cells to demonstrate the efficacy of the device for promoting endothelialization. These results indicated that the biofabricated device has great potential for use in tissue-engineering for various applications associated with the need of perfusable vasculature.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk apparatteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Equipment Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Textil-, gummi- och polymermaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Textile, Rubber and Polymeric Materials (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
Nyckelord
- 3D-bioprinting
- Biomimetic vascularized cell-delivery device
- Mold casting
- Nanocellulose-alginate hydrogel
- Endothelialization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sämfors, Sanna, ...
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Niemi, Essi M.
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Oskarsdotter, Kr ...
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Egea, Claudia Vi ...
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Mark, Andreas, 1 ...
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Scholz, Hanne
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visa fler...
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Gatenholm, Paul, ...
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visa färre...
- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Medicinteknik
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och Medicinsk appara ...
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Materialteknik
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och Textil gummi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Annan medicinsk ...
- Artiklar i publikationen
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Bioprinting
- Av lärosätet
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Chalmers tekniska högskola