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Habitual intakes of...
Habitual intakes of sugar-sweetened beverages associated with gut microbiota-related metabolites and metabolic health outcomes in young Chinese adults
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- Yan, Tao (författare)
- Shaanxi Normal University
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- Shi, Lin, 1988 (författare)
- Shaanxi Normal University,Chalmers tekniska högskola,Chalmers University of Technology
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Xu, Kun (författare)
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- Bai, Jinyu (författare)
- Shaanxi Normal University
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- Wen, Ruixue (författare)
- Shaanxi Normal University
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- Liao, Xia (författare)
- Xi'an Jiaotong University
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- Dai, Xiaoshuang (författare)
- BGI Institute of Applied Agriculture
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Wu, Qian (författare)
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Zeng, Lingxia (författare)
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- Peng, Wen (författare)
- Qinghai University
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Wang, Youfa (författare)
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Yan, Hong (författare)
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Dang, Shaonong (författare)
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Liu, Xin (författare)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
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Ingår i: Nutrition, Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 33:2, s. 359-368
- Relaterad länk:
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background and aims: Reducing consumption of sugar-sweetened beverages (SSBs) is a global public health priority because of their limited nutritional value and associations with increased risk of obesity and metabolic diseases. Gut microbiota-related metabolites emerged as quintessential effectors that may mediate impacts of dietary exposures on the modulation of host commensal microbiome and physiological status. Methods and results: This study assessed the associations among SSBs, circulating microbial metabolites, and gut microbiota–host co-metabolites, as well as metabolic health outcomes in young Chinese adults (n = 86), from the Carbohydrate Alternatives and Metabolic Phenotypes study in Shaanxi Province. Five principal component analysis-derived beverage drinking patterns were determined on self-reported SSB intakes, which were to a varying degree associated with 143 plasma levels of gut microbiota-related metabolites profiled by untargeted metabolomics. Moreover, carbonated beverages, fruit juice, energy drinks, and bubble tea exhibited positive associations with obesity-related markers and blood lipids, which were further validated in an independent cohort of 16,851 participants from the Regional Ethnic Cohort Study in Northwest China in Shaanxi Province. In contrast, presweetened coffee was negatively associated with the obesity-related traits. A total of 79 metabolites were associated with both SSBs and metabolic markers, particularly obesity markers. Pathway enrichment analysis identified the branched-chain amino acid catabolism and aminoacyl-tRNA biosynthesis as linking SSB intake with metabolic health outcomes. Conclusion: Our findings demonstrate the associations between habitual intakes of SSBs and several metabolic markers relevant to noncommunicable diseases, and highlight the critical involvement of gut microbiota-related metabolites in mediating such associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Sugar-sweetened beverage
- Metabolic health outcomes
- Plasma metabolome
- Gut microbiota
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- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yan, Tao
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Shi, Lin, 1988
-
Xu, Kun
-
Bai, Jinyu
-
Wen, Ruixue
-
Liao, Xia
-
visa fler...
-
Dai, Xiaoshuang
-
Wu, Qian
-
Zeng, Lingxia
-
Peng, Wen
-
Wang, Youfa
-
Yan, Hong
-
Dang, Shaonong
-
Liu, Xin
-
visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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Nutrition, Metab ...
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Chalmers tekniska högskola