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Freeze-dried bilber...
Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
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- Arevström, Lilith (författare)
- Örebro universitet,Örebro University,Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Bergh, Cecilia, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- Landberg, Rikard, 1981 (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Chalmers University of Technology,Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Göteborg, Sweden
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- Wu, Huaxing, 1987 (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för livsmedelsvetenskap,Department of Food Science,Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
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- Rodriguez-Mateos, Ana (författare)
- King's College London,Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK
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- Waldenborg, Micael, 1981- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Region Örebro län,Department of Cardiology
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- Magnuson, Anders (författare)
- Örebro universitet,Örebro University,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Swede
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- Blanc, Stepháne (författare)
- Université de Strasbourg,University of Strasbourg,Department of Ecology, Physiology and Ethology, Hubert Curien Pluridisciplinary Institute, University of Strasbourg, Strasbourg, France
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- Fröbert, Ole, 1964- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
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(creator_code:org_t)
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- Elsevier BV, 2019
- 2019
- Engelska.
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Ingår i: Nutrition Research. - : Elsevier BV. - 0271-5317 .- 1879-0739. ; 62, s. 13-22
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Abstract
Ämnesord
Stäng
- Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention in an 8- week trial either to V myrtillus powder (40 g/d, equivalent to 480 g fresh bilberries) and standard medical therapy or to a control group receiving standard medical therapy alone. High-sensitivity C-reactive protein and exercise capacity measured with the 6-minute walk test were the primary biochemical and clinical end points, respectively. Fifty subjects completed the study. No statistically significant difference in high-sensitivity C-reactive protein was detected between groups. The mean 6-minute walk test distance increased significantly more in the bilberry group compared to the control group: mean difference 38 m at follow-up (95% confidence interval 14- 62, P =.003). Ex vivo oxidized low-density lipoprotein was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% confidence interval 0.66-0.96, P =.017), whereas total cholesterol and low-density lipoprotein cholesterol did not differ significantly between groups. Anthocyanin-derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI; a larger, double-blind clinical trial is warranted to confirm this.
Ämnesord
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Anthocyanins
- Bilberries
- Exercise test
- Inflammation
- Cholesterol
- Myocardial Infarction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Arevström, Lilit ...
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Bergh, Cecilia, ...
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Landberg, Rikard ...
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Wu, Huaxing, 198 ...
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Rodriguez-Mateos ...
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Waldenborg, Mica ...
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visa fler...
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Magnuson, Anders
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Blanc, Stepháne
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Fröbert, Ole, 19 ...
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visa färre...
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och Livsmedelsvetens ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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MEDICIN OCH HÄLS ...
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och Kardiologi
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MEDICIN OCH HÄLS ...
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Nutrition Resear ...
- Av lärosätet
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Chalmers tekniska högskola
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Sveriges Lantbruksuniversitet
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Örebro universitet