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The role of peroxis...
The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae
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- Dzanaeva, Ljubov (författare)
- National Academy of Sciences in Ukraine
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- Kruk, Barbara (författare)
- University of Rzeszów
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- Ruchala, Justyna (författare)
- University of Rzeszów
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Sibirny, Andriy (författare)
- National Academy of Sciences in Ukraine
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- Dmytruk, Kostyantyn (författare)
- National Academy of Sciences in Ukraine
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(creator_code:org_t)
- 2020-04-13
- 2020
- Engelska.
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Ingår i: Cell Biology International. - : Wiley. - 1095-8355 .- 1065-6995. ; 44:8, s. 1606-1615
- Relaterad länk:
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https://research.cha...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Xylose is a second-most abounded sugar after glucose in lignocellulosic hydrolysates and should be efficiently fermented for economically viable second-generation ethanol production. Despite significant progress in metabolic and evolutionary engineering, xylose fermentation rate of recombinant Saccharomyces cerevisiae remains lower than that for glucose. Our recent study demonstrated that peroxisome-deficient cells of yeast Ogataea polymorpha showed a decrease in ethanol production from xylose. In this work, we have studied the role of peroxisomes in xylose alcoholic fermentation in the engineered xylose-utilizing strain of S. cerevisiae. It was shown that peroxisome-less pex3 Delta mutant possessed 1.5-fold decrease of ethanol production from xylose. We hypothesized that peroxisomal catalase Cta1 may have importance for hydrogen peroxide, the important component of reactive oxygen species, detoxification during xylose alcoholic fermentation. It was clearly shown that CTA1 deletion impaired ethanol production from xylose. It was found that enhancing the peroxisome population by modulation the peroxisomal biogenesis by overexpression of PEX34 activates xylose alcoholic fermentation.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Kemiska processer (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Chemical Process Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biokatalys och enzymteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Biocatalysis and Enzyme Technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Annan industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Other Industrial Biotechnology (hsv//eng)
Nyckelord
- cerevisiae
- alcoholic fermentation
- xylose
- peroxisomes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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