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Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

Omar, Adila, 1985 (författare)
Karolinska Institutet,Chalmers tekniska högskola,Chalmers University of Technology,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.;Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, S-41296 Gothenburg, Sweden.,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden
Frank, Jan (författare)
Universität Hohenheim,University of Hohenheim,Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunct, Garbenstr 28, D-70599 Stuttgart, Germany.,Department of Food Biofunctionality, Institute of Nutritional Sciences, University of Hohenheim, Garbenstr. 28, Stuttgart, Germany
Kruger, Johanita (författare)
Universität Hohenheim,University of Hohenheim,Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunct, Garbenstr 28, D-70599 Stuttgart, Germany.,Department of Food Biofunctionality, Institute of Nutritional Sciences, University of Hohenheim, Garbenstr. 28, Stuttgart, Germany
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Dal Bello, Federica (författare)
Universita degli Studi di Torino,University of Turin,Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy.,Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Medana, Claudio (författare)
Universita degli Studi di Torino,University of Turin,Univ Turin, Dept Mol Biotechnol & Hlth Sci, Turin, Italy.,Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
Collino, Massimo (författare)
Universita degli Studi di Torino,University of Turin,Univ Turin, Dept Drug Sci & Technol, Turin, Italy.,Department of Drug Science and Technology, University of Turin, Turin, Italy
Zamaratskaia, Galia (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish Univ Agr Sci, Dept Mol Sci, S-75007 Uppsala, Sweden.,Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden
Michaëlsson, Karl, 1959- (författare)
Uppsala universitet,Medicinsk epidemiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Landberg, Rikard, 1981 (författare)
Umeå universitet,Näringsforskning
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 (creator_code:org_t)
 
2021-02-25
2021
Engelska.
Ingår i: Molecular Nutrition and Food Research. - : Wiley. - 1613-4125 .- 1613-4133. ; 65:6
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Scope A high fructose and galactose intake show adverse metabolic effects in animal models and in humans, but it is yet unknown if addition of fermentable dietary fiber can mitigate such effects. This study investigate the effects of high intakes of fructose and galactose, with/without added fructooligosaccharides (FOS), on metabolic factors, inflammation, and gut integrity markers in rats. Methods and Results Rats (n = 6/group) receive different carbohydrates at isocaloric conditions for 12 weeks as follows: 1) starch (control), 2) fructose, 3) galactose, 4) starch + FOS (FOS control), 5) fructose + FOS, and 6) galactose + FOS, together with a high amount of n-6 polyunsaturated fatty acids (n-6 PUFA) in all diets except for in 7) starch + olive oil (negative control). The rats fed the galactose and galactose + FOS diets exhibit lower body weight than other groups. High-galactose diets has more pronounced effects on metabolic factors and gut permeability than high-fructose diets. High-fructose diets show less pronounced effect on these selected markers. No differences in inflammatory markers are detected for any of the diets. Conclusions The results suggest potential adverse effects of high galactose and fructose on metabolic factors and gut integrity markers, but not on inflammation. However, several mechanisms are at play, and general net effects are difficult to determine conclusively for the conditions tested.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
LANTBRUKSVETENSKAPER  -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
AGRICULTURAL SCIENCES  -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

fructose
galactose
fructooligosaccharides
inflammatory markers
gut integrity

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art (ämneskategori)
ref (ämneskategori)

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