Sökning: onr:"swepub:oai:research.chalmers.se:394b25a3-7c43-4b49-b57d-44bb660b7b10" >
Dietary Intake of F...
Dietary Intake of Fructooligosaccharides Protects against Metabolic Derangements Evoked by Chronic Exposure to Fructose or Galactose in Rats
-
- Almasri, Fidele (författare)
- Universität Hohenheim,University of Hohenheim
-
- Collotta, Debora (författare)
- Universita degli Studi di Torino,University of Turin
-
- Aimaretti, Eleonora (författare)
- Universita degli Studi di Torino,University of Turin
-
visa fler...
-
- Sus, Nadine (författare)
- Universität Hohenheim,University of Hohenheim
-
- Aragno, Manuela (författare)
- Universita degli Studi di Torino,University of Turin
-
- Dal Bello, Federica (författare)
- Universita degli Studi di Torino,University of Turin
-
- Eva, Carola (författare)
- Universita degli Studi di Torino,University of Turin
-
- Mastrocola, Raffaella (författare)
- Universita degli Studi di Torino,University of Turin
-
- Landberg, Rikard, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Frank, Jan (författare)
- Universität Hohenheim,University of Hohenheim
-
- Collino, Massimo (författare)
- Universita degli Studi di Torino,University of Turin
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska.
-
Ingår i: Molecular Nutrition and Food Research. - 1613-4125 .- 1613-4133. ; 68:4
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://research.cha...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- ScopeDiets rich in fat and sugars evoke chronic low-grade inflammation, leading to metabolic derangements. This study investigates the impact of fructose and galactose, two commonly consumed simple sugars, on exacerbation of the harmful effects caused by high fat intake. Additionally, the potential efficacy of fructooligosaccharides (FOS), a fermentable dietary fiber, in counteracting these effects is examined.Methods and resultsMale Sprague-Dawley rats (six/group) are fed 8 weeks as follows: control 5% fat diet (CNT), 20% fat diet (FAT), FAT+10% FOS diet (FAT+FOS), FAT+25% galactose diet (FAT+GAL), FAT+GAL+10% FOS diet (FAT+GAL+FOS), FAT+25% fructose diet (FAT+FRU), FAT+FRU+10% FOS diet (FAT+FRU+FOS). The dietary manipulations tested do not affect body weight gain, blood glucose, or markers of systemic inflammation whereas significant increases in plasma concentrations of triacylglycerols, cholesterol, aspartate aminotransferase, and alanine aminotrasferase are detected in both FAT+FRU and FAT+GAL compared to CNT. In the liver and skeletal muscle, both sugars induce significant accumulation of lipids and advanced glycation end-products (AGEs). FOS supplementation prevents these impairments.ConclusionThis study extends the understanding of the deleterious effects of a chronic intake of simple sugars and demonstrates the beneficial role of the prebiotic FOS in dampening the sugar-induced metabolic impairments by prevention of lipid and AGEs accumulation. This rat trial shows the detrimental effects of two commonly consumed simple sugars, fructose and galactose, when added to a fat-enriched diet, as is common in modern Western nutrition. Protective effects of fermentable dietary fiber (FOS) supplementation due to reduced accumulation of AGEs, that are harmful compounds formed when protein or fat combine with sugar, are observed.image
Ämnesord
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- blood lipids
- cytokines
- inflammation
- liver lipid accumulation
- advanced glycation end-products
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Almasri, Fidele
-
Collotta, Debora
-
Aimaretti, Eleon ...
-
Sus, Nadine
-
Aragno, Manuela
-
Dal Bello, Feder ...
-
visa fler...
-
Eva, Carola
-
Mastrocola, Raff ...
-
Landberg, Rikard ...
-
Frank, Jan
-
Collino, Massimo
-
visa färre...
- Om ämnet
-
- LANTBRUKSVETENSKAPER
-
LANTBRUKSVETENSK ...
-
och Lantbruksvetensk ...
-
och Livsmedelsvetens ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
Molecular Nutrit ...
- Av lärosätet
-
Chalmers tekniska högskola