Mapping the chemistry of hair strands by mass spectrometry imaging - A Review

Philipsen, Mai H.Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molekylär evolution,Forskargrupper vid Lunds universitet,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Molecular Evolution,Lund University Research Groups (författare)

Hair can record chemical information reflecting our living conditions, and, therefore, strands of hair have become a potent analytical target within the biological and forensic sciences. While early efforts focused on analyzing complete hair strands in bulk, high spatial resolution mass spectrometry imaging (MSI) has recently come to the forefront of chemical hair-strand analysis. MSI techniques offer a localized analysis, requiring fewer de-contamination procedures per default and making it possible to map the distribution of analytes on and within individual hair strands. Applying the techniques to hair samples has proven particularly useful in investigations quantifying the exposure to, and uptake of, toxins or drugs. Overall, MSI, combined with optimized sample preparation protocols, has improved precision and accuracy for identifying several elemental and molecular species in single strands of hair. Here, we review different sample preparation protocols and use cases with a view to make the methodology more accessible to researchers outside of the field of forensic science. We conclude that-although some challenges remain, including contamination issues and matrix effects-MSI offers unique opportunities for obtaining highly resolved spatial information of several compounds simultaneously across hair surfaces.

Haxen, Emma R.Lunds universitet,Lund University,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molekylär evolution,Forskargrupper vid Lunds universitet,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Molecular Evolution,Lund University Research Groups(Swepub:lu)em5613ha (författare)
Manaprasertsak, AurayaLund University,Lunds universitet,Molekylär evolution,Forskargrupper vid Lunds universitet,Molecular Evolution,Lund University Research Groups(Swepub:lu)au8432ma (författare)
Malmberg, Per,1974Chalmers University of Technology(Swepub:cth)malmper (författare)
Hammarlund, Emma U.Lunds universitet,Lund University,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molekylär evolution,Forskargrupper vid Lunds universitet,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Molecular Evolution,Lund University Research Groups(Swepub:lu)med-ehd (författare)
Avdelningen för translationell cancerforskningInstitutionen för laboratoriemedicin (creator_code:org_t)

Av författaren/redakt...: Philipsen, Mai H ...; Haxen, Emma R.; Manaprasertsak, ...; Malmberg, Per, 1 ...; Hammarlund, Emma ...

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