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Development of meta...
Development of metallocomplex amino acids synthons for the asymmetric preparation of α-amino acids by stereoselective introduction of a side chain. Evaluation of the model asymmetric preparation of alanine and β-13C monolabelled α-aminoisobutyric acid
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Popkov, Alexander (författare)
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- Hanusek, Jiri (författare)
- University of Pardubice
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- Cermak, Jiri (författare)
- Vuzkumnu ustav organickuch syntez a.s
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- Langer, Vratislav, 1949 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Jirasko, Robert (författare)
- University of Pardubice
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- Holcapek, Michal (författare)
- University of Pardubice
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- Nadvornik, Milan (författare)
- University of Pardubice
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University of Pardubice Vuzkumnu ustav organickuch syntez as (creator_code:org_t)
- 2010-05-01
- 2010
- Engelska.
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Ingår i: Journal of Radioanalytical and Nuclear Chemistry. - : Springer Science and Business Media LLC. - 0236-5731 .- 1588-2780. ; 285:3, s. 621-626
- Relaterad länk:
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http://dx.doi.org/10...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In this communication the evaluation of eleven new metallocomplex alanine synthons bearing C2-symmetric benzyl groups with electron-donating and electron-withdrawing substituents is described. α-Methylated glycine synthons (alanine complexes) were evaluated alongside alanine synthons in order to obtain a deeper understanding of the relationship between their structures and stereochemistry of monoalkylated products and to choose several candidates for their further tests for stereospecific preparation of 6-[18F]FDOPA. Glycine-derived analogues of the complexes 3–5 are the best candidates for the development of a 6-[18F]FDOPA preparation procedure. In the model epimerisation reaction they demonstrated the best performance, much better compared to the previously described compound 2. Complexes 3, 5 and 8 are the best in asymmetric preparation of β-13C monolabelled α-aminoisobutyric acid. They have to be tested in the preparation of α-methyl amino acids like 6-[18F]-α-methylDOPA and 2-[18F]-α-methyltyrosine.
Ämnesord
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Nickel
- stereoselectivity
- PET
- Schiff bases
- 6[<sup>18</sup>F]FDOPA
- Amino acids
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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