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Sökning: onr:"swepub:oai:research.chalmers.se:7c2f4f1f-a894-49c6-94c4-0af6d57be175" > Whole-cell modeling...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004648naa a2200529 4500
001oai:research.chalmers.se:7c2f4f1f-a894-49c6-94c4-0af6d57be175
003SwePub
008220219s2022 | |||||||||||000 ||eng|
0247 a https://doi.org/10.1038/s41467-022-28467-62 DOI
0247 a https://research.chalmers.se/publication/5287192 URI
040 a (SwePub)cth
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a El-Semman, Ibrahim,d 1977u Danmarks Tekniske Universitet,Technical University of Denmark,Assiut University4 aut0 (Swepub:cth)elsemman
2451 0a Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies
264 c 2022-02-10
264 1b Springer Science and Business Media LLC,c 2022
338 a electronic2 rdacarrier
520 a When conditions change, unicellular organisms rewire their metabolism to sustain cell maintenance and cellular growth. Such rewiring may be understood as resource re-allocation under cellular constraints. Eukaryal cells contain metabolically active organelles such as mitochondria, competing for cytosolic space and resources, and the nature of the relevant cellular constraints remain to be determined for such cells. Here, we present a comprehensive metabolic model of the yeast cell, based on its full metabolic reaction network extended with protein synthesis and degradation reactions. The model predicts metabolic fluxes and corresponding protein expression by constraining compartment-specific protein pools and maximising growth rate. Comparing model predictions with quantitative experimental data suggests that under glucose limitation, a mitochondrial constraint limits growth at the onset of ethanol formation-known as the Crabtree effect. Under sugar excess, however, a constraint on total cytosolic volume dictates overflow metabolism. Our comprehensive model thus identifies condition-dependent and compartment-specific constraints that can explain metabolic strategies and protein expression profiles from growth rate optimisation, providing a framework to understand metabolic adaptation in eukaryal cells.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
7001 a Rodriguez Prado, Angelicau Vrije Universiteit Amsterdam (VU),Technische Universiteit Delft,Delft University of Technology (TU Delft)4 aut
7001 a Grigaitis, Pranasu Vrije Universiteit Amsterdam (VU)4 aut
7001 a Garcia, Manuel,d 1973u University of Manchester4 aut0 (Swepub:cth)gmanuel
7001 a Harman, Victoriau University of Liverpool4 aut
7001 a Holman, Stephen W.u University of Liverpool4 aut
7001 a van Heerden, Johanu Vrije Universiteit Amsterdam (VU)4 aut
7001 a Bruggeman, Frank J.u Vrije Universiteit Amsterdam (VU)4 aut
7001 a Bisschops, Mark,d 1985u Technische Universiteit Delft,Delft University of Technology (TU Delft)4 aut0 (Swepub:cth)bishops
7001 a Sonnenschein, N.u Danmarks Tekniske Universitet,Technical University of Denmark4 aut
7001 a Hubbard, Simonu University of Manchester4 aut
7001 a Beynon, Robu University of Liverpool4 aut
7001 a Daran-Lapujade, P.u Technische Universiteit Delft,Delft University of Technology (TU Delft)4 aut
7001 a Nielsen, Jens B,d 1962u Danmarks Tekniske Universitet,Technical University of Denmark,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)nielsenj
7001 a Teusink, B.u Vrije Universiteit Amsterdam (VU)4 aut
7102 a Danmarks Tekniske Universitetb Assiut University4 org
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 13:1q 13:1x 2041-1723x 2041-1723
8564 u https://research.chalmers.se/publication/528719/file/528719_Fulltext.pdfx primaryx freey FULLTEXT
8564 u https://www.nature.com/articles/s41467-022-28467-6.pdf
8564 8u https://doi.org/10.1038/s41467-022-28467-6
8564 8u https://research.chalmers.se/publication/528719

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