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Sökning: onr:"swepub:oai:research.chalmers.se:814a40a1-f18f-485c-af20-4a0415fb7bb0" > Comparative genomic...

Comparative genomics study reveals Red Sea Bacillus with characteristics associated with potential microbial cell factories (MCFs)

Othoum, Ghofran (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Prigent, Sylvain, 1984 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Div Syst & Synthet Biol, Dept Biol & Biol Engn, Kemivaen 10, S-41296 Gothenburg, Sweden.
Derouiche, Abderahmane, 1980 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Div Syst & Synthet Biol, Dept Biol & Biol Engn, Kemivaen 10, S-41296 Gothenburg, Sweden.
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Shi, Lei, 1981 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Div Syst & Synthet Biol, Dept Biol & Biol Engn, Kemivaen 10, S-41296 Gothenburg, Sweden.
Bokhari, Ameerah (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, Biol & Environm Sci & Engn Div BESE, Thuwal 239556900, Saudi Arabia.
Alamoudi, Soha (författare)
King Abdulaziz University,King Abdulaziz Univ, Dept Biol, Sci & Arts Coll, Rabigh 21589, Saudi Arabia.
Bougouffa, Salim (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Gao, X. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Hoehndorf, Robert (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Arold, Stefan T. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Gojobori, T. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.;KAUST, Biol & Environm Sci & Engn Div BESE, Thuwal 239556900, Saudi Arabia.
Hirt, H. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, Biol & Environm Sci & Engn Div BESE, Thuwal 239556900, Saudi Arabia.
Lafi, Feras F. (författare)
King Abdullah University of Science and Technology (KAUST),Zayed University,KAUST, CBRC, Thuwal 239556900, Saudi Arabia.;Zayed Univ, Coll Nat & Hlth Sci, Abu Dhabi 144534, U Arab Emirates.
Nielsen, Jens B, 1962 (författare)
KTH,Science for Life Laboratory, SciLifeLab
Bajic, Vladimir B. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
Mijakovic, Ivan, 1975 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Novo Nordisk Fonden,Novo Nordisk Foundation,Chalmers Univ Technol, Div Syst & Synthet Biol, Dept Biol & Biol Engn, Kemivaen 10, S-41296 Gothenburg, Sweden.;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark.
Essack, M. (författare)
King Abdullah University of Science and Technology (KAUST),KAUST, CBRC, Thuwal 239556900, Saudi Arabia.
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King Abdullah University of Science and Technology (KAUST) KAUST, CBRC, Thuwal 239556900, Saudi Arabia (creator_code:org_t)
2019-12-17
2019
Engelska.
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322 .- 2045-2322. ; 9:1
Relaterad länk:
https://research.cha... (primary) (free)
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https://www.nature.c...
https://doi.org/10.1...
https://research.cha...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Recent advancements in the use of microbial cells for scalable production of industrial enzymes encourage exploring new environments for efficient microbial cell factories (MCFs). Here, through a comparison study, ten newly sequenced Bacillus species, isolated from the Rabigh Harbor Lagoon on the Red Sea shoreline, were evaluated for their potential use as MCFs. Phylogenetic analysis of 40 representative genomes with phylogenetic relevance, including the ten Red Sea species, showed that the Red Sea species come from several colonization events and are not the result of a single colonization followed by speciation. Moreover, clustering reactions in reconstruct metabolic networks of these Bacillus species revealed that three metabolic clades do not fit the phylogenetic tree, a sign of convergent evolution of the metabolism of these species in response to special environmental adaptation. We further showed Red Sea strains Bacillus paralicheniformis (Bac48) and B. halosaccharovorans (Bac94) had twice as much secreted proteins than the model strain B. subtilis 168. Also, Bac94 was enriched with genes associated with the Tat and Sec protein secretion system and Bac48 has a hybrid PKS/NRPS cluster that is part of a horizontally transferred genomic region. These properties collectively hint towards the potential use of Red Sea Bacillus as efficient protein secreting microbial hosts, and that this characteristic of these strains may be a consequence of the unique ecological features of the isolation environment. © 2019, The Author(s).

Ämnesord

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Botanik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Botany (hsv//eng)
NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

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