Sökning: onr:"swepub:oai:research.chalmers.se:8b87b9e0-bbba-4055-8f20-01cf7e2a02dd" > Asymmetric cationic...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04184naa a2200529 4500 | |
001 | oai:research.chalmers.se:8b87b9e0-bbba-4055-8f20-01cf7e2a02dd | |
003 | SwePub | |
008 | 171008s2017 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/255083 | |
024 | 7 | a https://doi.org/10.1016/j.colsurfb.2016.06.0412 DOI |
024 | 7 | a https://research.chalmers.se/publication/2478882 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2550832 URI |
040 | a (SwePub)cthd (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Jing, Yujia,d 1985u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)yujia |
245 | 1 0 | a Asymmetric cationic liposomes designed for heat-activated association with cells |
264 | 1 | b Elsevier BV,c 2017 |
520 | a Improved anticancer drugs and drug carriers are needed in combination therapies, such as hyperthermia-assisted chemotherapy. Liposomal drug carriers with advanced functions are attractive candidates for targeted accumulation and drug release in response to heat stimulus. We report on the design of liposomes with a heat-activated surface function. Our design is based on asymmetric lipid membranes with a defined gel to liquid-crystalline phase-transition temperature around 41 °C. Asymmetry between the inner and the outer membrane leaflets was generated through selective PEGylation of cationic lipids in the outer membrane leaflet. In a physiological buffer, the PEGylated asymmetric liposomes had a neutral zeta potential and did not bind to planar anionic model membranes. In contrast, following upon heat-activation, binding of liposomes to the model membranes occurred. Release of a hydrophilic dye encapsulated in the asymmetric liposomes occurred at 40 °C. Enhanced uptake of the asymmetric liposomes by hypopharyngeal carcinoma cells (FaDu cells) was observed when hyperthermia was applied compared to experiments performed at 37 °C. These results show the potential of asymmetric liposomes for localized delivery of drugs into cells in response to (external) temperature stimulus. | |
650 | 7 | a NATURVETENSKAPx Fysik0 (SwePub)1032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Physical Sciences0 (SwePub)1032 hsv//eng |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Elektroteknik och elektronik0 (SwePub)2022 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Electrical Engineering, Electronic Engineering, Information Engineering0 (SwePub)2022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Cationic liposomes | |
653 | a PEGylation | |
653 | a Hyperthermia | |
653 | a Cellular uptake | |
653 | a Membrane asymmetry | |
653 | a Cationic liposomes | |
653 | a Cellular uptake | |
653 | a Hyperthermia | |
653 | a Membrane asymmetry | |
653 | a PEGylation | |
700 | 1 | a Danielsson, Anna,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Oncology4 aut0 (Swepub:gu)xdanne |
700 | 1 | a Dobsicek Trefna, Hana,d 1979u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)hanatre |
700 | 1 | a Persson, Mikael,d 1959u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)elfmp |
700 | 1 | a Svedhem, Sofia,d 1970u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)sofsv |
710 | 2 | a Chalmers tekniska högskolab Institutionen för kliniska vetenskaper, Avdelningen för onkologi4 org |
773 | 0 | t Colloids and Surfaces B: Biointerfacesd : Elsevier BVg 151, s. 112-118q 151<112-118x 0927-7765x 1873-4367 |
856 | 4 | u http://dx.doi.org/10.1016/j.colsurfb.2016.06.041y FULLTEXT |
856 | 4 8 | u https://doi.org/10.1016/j.colsurfb.2016.06.041 |
856 | 4 8 | u https://research.chalmers.se/publication/247888 |
856 | 4 8 | u https://gup.ub.gu.se/publication/255083 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.