Sökning: onr:"swepub:oai:research.chalmers.se:8dece373-1cff-48e0-9166-505d7848d011" > Spreading depressio...
Fältnamn | Indikatorer | Metadata |
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000 | 03486naa a2200421 4500 | |
001 | oai:research.chalmers.se:8dece373-1cff-48e0-9166-505d7848d011 | |
003 | SwePub | |
008 | 171008s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://research.chalmers.se/publication/1989662 URI |
024 | 7 | a https://doi.org/10.1002/jnr.234122 DOI |
040 | a (SwePub)cth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Broberg, Marita,d 1973u Flinders University of South Australia4 aut |
245 | 1 0 | a Spreading depression: Evidence of five electroencephalogram phases. |
264 | c 2014-05-20 | |
264 | 1 | b Wiley,c 2014 |
520 | a Spreading depression (SD), a self-propagating wave of astroglial and neuronal depolarization, is an accompaniment of several neurological disorders including epilepsy. Its well-described features are initial depolarization, followed by EEG flattening. In this in vivo study in awake animals, the relationship of SDs to epileptiform activity was re-examined. We assessed SDs generated by mechanical stimulation and by metabolic inhibition with fluorocitrate. In addition to identifying prolonged EEG depression, we identified two periods, one prior to and another during depression, characterized by increases in power of specific frequencies that were sometimes associated with epileptiform discharges. The first period was characterized by ripple activity close to the induction site (88% of SDs with intracortical electrodes). The second period was characterized by localized low-frequency spikes (100% with dural screw electrodes, 65% with intracortical electrodes). By using fluorocitrate to induce SDs, the initial period was also characterized by runs of spikes (52%). Finally, with SDs induced by both methods, there was a period at the end of depression when additional, unprovoked SDs occurred (20%). Five stages of SD were defined by these phenomena, in the order: excitation, depression, excitation, depression, SD, with metabolic inhibition enhancing the expression of epileptiform spiking. | |
650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Medicinsk laboratorie- och mätteknik0 (SwePub)206012 hsv//swe |
650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Medical Laboratory and Measurements Technologies0 (SwePub)206012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a high-frequency activity | |
653 | a impedance | |
653 | a fluorocitrate | |
653 | a ripples | |
653 | a epileptiform discharges | |
700 | 1 | a Pope, Kennethu Flinders University of South Australia4 aut |
700 | 1 | a Olsson, Torsten,d 1937u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)torsten |
700 | 1 | a William Shuttleworth, Cu University of New Mexico4 aut |
700 | 1 | a Willoughby, Johnu Flinders University of South Australia4 aut |
710 | 2 | a Flinders University of South Australiab Chalmers tekniska högskola4 org |
773 | 0 | t Journal of Neuroscience Researchd : Wileyg 92:10, s. 1384-1394q 92:10<1384-1394x 0360-4012x 1097-4547 |
856 | 4 | u http://dx.doi.org/10.1002/jnr.23412y FULLTEXT |
856 | 4 8 | u https://research.chalmers.se/publication/198966 |
856 | 4 8 | u https://doi.org/10.1002/jnr.23412 |
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