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Higher intake of fi...
Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study
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- Vendelbo Lind, Mads, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Lauritzen, Lotte (författare)
- Köpenhamns universitet,University of Copenhagen
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- Pedersen, Oluf (författare)
- Köpenhamns universitet,University of Copenhagen
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- Vestergaard, Henrik (författare)
- Köpenhamns universitet,University of Copenhagen,Steno Diabetes Center
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- Stark, Ken D. (författare)
- University of Waterloo
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- Hansen, Torben (författare)
- Köpenhamns universitet,University of Copenhagen
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- Ross, Alastair, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kristensen, M. (författare)
- Köpenhamns universitet,University of Copenhagen
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Nutrition Research. - : Elsevier BV. - 0271-5317 .- 1879-0739. ; 46, s. 78-87
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (?4.7% (?9.3; 0.0), P =.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (?0.5; 5.5), P =.08; 5.8% (?0.2; 12.1), P =.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (?5.4% (?9.7; ?0.8), P =.02 and ?7.0% (?12.1; ?1.5), P =.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P =.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Whole grain
- Homocysteine
- Long-chain polyunsaturated fatty acids
- Methyl donor metabolism
- Dietary patterns
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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