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From next-generatio...
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Ji, Boyang,1983Chalmers tekniska högskola,Chalmers University of Technology
(författare)
From next-generation sequencing to systematic modeling of the gut microbiome
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015-06-23
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Frontiers Media SA,2015
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:research.chalmers.se:9dffcf69-e31b-4b2e-8813-7aba548c9ad6
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https://doi.org/10.3389/fgene.2015.00219DOI
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https://research.chalmers.se/publication/223791URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:for swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Changes in the human gut microbiome are associated with altered human metabolism and health, yet the mechanisms of interactions between microbial species and human metabolism have not been clearly elucidated. Next-generation sequencing has revolutionized the human gut microbiome research, but most current applications concentrate on studying the microbial diversity of communities and have at best provided associations between specific gut bacteria and human health. However, little is known about the inner metabolic mechanisms in the gut ecosystem. Here we review recent progress in modeling the metabolic interactions of gut microbiome, with special focus on the utilization of metabolic modeling to infer host-microbe interactions and microbial species interactions. The systematic modeling of metabolic interactions could provide a predictive understanding of gut microbiome, and pave the way to synthetic microbiota design and personalized-microbiome medicine and healthcare. Finally, we discuss the integration of metabolic modeling and gut microbiome engineering, which offer a new way to explore metabolic interactions across members of the gut microbiota.
Ämnesord och genrebeteckningar
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NATURVETENSKAP Biologi hsv//swe
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NATURAL SCIENCES Biological Sciences hsv//eng
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Personalized medicine
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Systematic modeling
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Gut microbiome
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microbial community
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microbial metabolism
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Next-generation sequencing
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microbiome
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Review
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molecular interaction
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Species interactome
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methanogenesis
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human
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nonhuman
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phenotype
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intestine flora
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next generation sequencing
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model
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metagenomics
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Metabolic modeling
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj
(författare)
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Chalmers tekniska högskola
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Frontiers in Genetics: Frontiers Media SA6:JUN1664-8021
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