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Metabolic engineeri...
Metabolic engineering of isoprenoid production: Reconstruction of multistep heterologous pathways in tractable hosts
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- Maury, J. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
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- Asadollahi, M. A. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
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- Formenti, L. R. (författare)
- Danmarks Tekniske Universitet,Technical University of Denmark
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Michel, S. (författare)
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- ISBN 9781461440635
- 2012-08-22
- 2013
- Engelska.
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Ingår i: Isoprenoid Synthesis in Plants and Microorganisms: New Concepts and Experimental Approaches. - New York, NY : Springer New York. - 9781461440635 ; , s. 73-89
- Relaterad länk:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Isoprenoids represent a wide group of chemically active compounds that can find a wide range of applications as flavors, perfumes, vitamins, nutraceuticals, and pharmaceuticals. Many isoprenoids are naturally produced in very low quantities by plants, which make their use in broader perspectives difficult. Microbial production of plant-originating isoprenoids quickly appeared as an alternative of choice. Metabolic engineering methods were applied and proved successful to improve the supply of precursors to derive toward isoprenoid compounds of interest. Combinations between metabolic engineering and the flourishing field of synthetic biology have also been observed with researchers attempting to reconstruct and optimize complex biosynthetic pathways in well-characterized and tractable microbial hosts. In this chapter, we review recent metabolic engineering studies for isoprenoid production in yeast and try to show, through key examples, that the fields of synthetic biology and metabolic engineering can go hand in hand to establish microbial cell factories for isoprenoid production.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- MEP pathway
- Heterologous gene
- Synthetic biology
- Metabolic engineering
- Mevalonate pathway
- Yeast
- Saccharomyces cerevisiae
Publikations- och innehållstyp
- kap (ämneskategori)
- vet (ämneskategori)
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