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Evaluating accessib...
Evaluating accessibility, usability and interoperability of genome-scale metabolic models for diverse yeasts species
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- Domenzain Del Castillo Cerecer, Iván, 1991 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Li, Feiran, 1993 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kerkhoven, Eduard, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Siewers, Verena, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa färre...
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(creator_code:org_t)
- 2021-01-11
- 2021
- Engelska.
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Ingår i: FEMS Yeast Research. - : Oxford University Press (OUP). - 1567-1356 .- 1567-1364. ; 21:1
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://academic.oup...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Metabolic network reconstructions have become an important tool for probing cellular metabolism in the field of systems biology. They are used as tools for quantitative prediction but also as scaffolds for further knowledge contextualization. The yeast Saccharomyces cerevisiae was one of the first organisms for which a genome-scale metabolic model (GEM) was reconstructed, in 2003, and since then 45 metabolic models have been developed for a wide variety of relevant yeasts species. A systematic evaluation of these models revealed that-despite this long modeling history-the sequential process of tracing model files, setting them up for basic simulation purposes and comparing them across species and even different versions, is still not a generalizable task. These findings call the yeast modeling community to comply to standard practices on model development and sharing in order to make GEMs accessible and useful for a wider public.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Annan data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Other Computer and Information Science (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Datorsystem (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Computer Systems (hsv//eng)
Nyckelord
- yeast species
- systems biology
- accessibility
- usability
- interoperability
- genome-scale metabolic models
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