Sökning: onr:"swepub:oai:research.chalmers.se:bff368a4-4200-4f17-abea-a90b79a38954" >
Evidence of Couplin...
Evidence of Coupling between the Motions of Water and Peptides
-
- Cerveny, S. (författare)
- Centro de Física de Materiales (CSIC-UPV/EHU),Donostia International Physics Center
-
- Combarro-Palacios, I. (författare)
- Centro de Física de Materiales (CSIC-UPV/EHU)
-
- Swenson, Jan, 1966 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
(creator_code:org_t)
- 2016-10-04
- 2016
- Engelska.
-
Ingår i: Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 7:20, s. 4093-4098
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://doi.org/10.1...
-
https://research.cha...
-
visa färre...
Abstract
Ämnesord
Stäng
- Studies of protein dynamics at low temperatures are generally performed on hydrated powders and not in biologically realistic solutions of water because of water crystallization. However, here we avoid the problem of crystallization by reducing the size of the biomolecules. We have studied oligomers of the amino acid L-lysine, fully dissolved in water, and our dielectric relaxation data show that the glass transition-related dynamics of the oligomers is determined by the water dynamics, in a way similar to that previously observed for solvated proteins. This implies that the crucial role of water for protein dynamics can be extended to other types of macromolecular systems, where water is also able to determine their conformational fluctuations. Using the energy landscape picture of macromolecules, the thermodynamic criterion for such solvent-slaved macromolecular motions may be that the macromolecules need the entropy contribution from the solvent to overcome the enthalpy barriers between different conformational substates.
Ämnesord
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Nyckelord
- WATER
- V106
- SUPERCOOLED
- PROTEIN DYNAMICS
- SOLVENT
- HYDRATION WATER
- P5129
- Materials Science
- BOVINE SERUM-ALBUMIN
- Chemistry
- Molecular & Chemical
- Physics
- CONFINED WATER
- RELAXATION
- Atomic
- GLASS-TRANSITION
- LYSINE
- ATES OF AMERICA
- Nanoscience & Nanotechnology
- MYOGLOBIN
- Physical
- Multidisciplinary
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas