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Genome-scale metabo...
Genome-scale metabolic models applied for human health and biopharmaceutical engineering
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- Li, Feiran, 1993 (författare)
- Tsinghua University
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- Chen, Yu, 1990 (författare)
- Shenzhen Institute of Advanced Technology
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- Gustafsson, Johan, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Wang, Hao, 1975 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Wang, Yi (författare)
- Tsinghua University
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- Zhang, Chong (författare)
- Tsinghua University
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- Xing, Xinhui (författare)
- Tsinghua University
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Quantitative Biology. - 2095-4689 .- 2095-4697. ; 11:4, s. 363-375
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Over the last 15 years, genome-scale metabolic models (GEMs) have been reconstructed for human and model animals, such as mouse and rat, to systematically understand metabolism, simulate multicellular or multi-tissue interplay, understand human diseases, and guide cell factory design for biopharmaceutical protein production. Here, we describe how metabolic networks can be represented using stoichiometric matrices and well-defined constraints for flux simulation. Then, we review the history of GEM development for quantitative understanding of Homo sapiens and other relevant animals, together with their applications. We describe how model develops from H. sapiens to other animals and from generic purpose to precise context-specific simulation. The progress of GEMs for animals greatly expand our systematic understanding of metabolism in human and related animals. We discuss the difficulties and present perspectives on the GEM development and the quest to integrate more biological processes and omics data for future research and translation. We truly hope that this review can inspire new models developed for other mammalian organisms and generate new algorithms for integrating big data to conduct more in-depth analysis to further make progress on human health and biopharmaceutical engineering.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Programvaruteknik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Software Engineering (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- constraint-based modeling
- genome-scale metabolic model
- disease
- metabolism
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Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Li, Feiran, 1993
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Chen, Yu, 1990
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Gustafsson, Joha ...
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Wang, Hao, 1975
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Wang, Yi
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Zhang, Chong
-
visa fler...
-
Xing, Xinhui
-
visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Data och informa ...
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och Programvarutekni ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
- Artiklar i publikationen
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Quantitative Bio ...
- Av lärosätet
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Chalmers tekniska högskola