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Use of genome-scale...
Use of genome-scale metabolic models for understanding microbial physiology
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- Liu, Liming, 1976 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Ågren, Rasmus, 1982 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Velasco, Sergio, 1980 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa fler...
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- Nielsen, Jens B, 1962 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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visa färre...
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(creator_code:org_t)
- 2010-04-24
- 2010
- Engelska.
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Ingår i: FEBS Letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 584:12, s. 2556-2564
- Relaterad länk:
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http://dx.doi.org/10...
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https://febs.onlinel...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- The exploitation of microorganisms in industrial, medical, food and environmental biotechnology requires a comprehensive understanding of their physiology. The availability of genome sequences and accumulation of high-throughput data allows gaining understanding of microbial physiology at the systems level, and genome-scale metabolic models represent a valuable framework for integrative analysis of metabolism of microorganisms. Genome-scale metabolic models are reconstructed based on a combination of genome sequence information and detailed biochemical information, and these reconstructed models can be used for analyzing and simulating the operation of metabolism in response to different stimuli. Here we discuss the requirement for having detailed physiological insight in order to exploit microorganisms for production of fuels, chemicals and pharmaceuticals. We further describe the reconstruction process of genome-scale metabolic models and different algorithms that can be used to apply these models to gain improved insight into microbial physiology. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
Nyckelord
- escherichia-coli
- Algorithm
- transcriptional regulation
- information-retrieval
- Genome-scale metabolic model
- Reconstruction
- Microbial
- flux-balance analysis
- essential genes
- yeast
- intracellular environment
- framework
- amino-acids
- optimization
- physiology
- cell-envelope
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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