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Analysis of mesosca...
Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model
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- Abrahamsson, Per, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Kvist, Patric (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Reynolds, G. (författare)
- AstraZeneca AB
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- Yu, X. (författare)
- Aston University
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- Bjorn, I. N. (författare)
- AstraZeneca AB
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- Hounslow, M. J. (författare)
- University of Sheffield
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- Rasmuson, Anders, 1951 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Particuology. - : Elsevier BV. - 2210-4291 .- 1674-2001. ; 36, s. 1-12
- Relaterad länk:
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https://publications...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Geofysisk teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Geophysical Engineering (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Strömningsmekanik och akustik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Fluid Mechanics and Acoustics (hsv//eng)
Nyckelord
- Computational fluid dynamics
- High-shear wet granulation
- Compartment model
- Population-balance model
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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