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Consumption of whol...
Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer
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- Zamaratskaia, Galia (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish University of Agricultural Sciences, Department of Molecular Sciences, Box, 7015, Uppsala, Sweden.
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- Mhd Omar, Nor Adila (författare)
- Karolinska Institutet
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- Brunius, Carl, 1974 (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Chalmers University of Technology,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Chalmers tekniska högskola,Swedish University of Agricultural Sciences, Department of Molecular Sciences, Box, 7015, Uppsala, Sweden; Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning,Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden.
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- Johansson, Jan Erik (författare)
- Örebro universitet,Örebro University,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
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- Andersson, Sven Olof (författare)
- Örebro universitet,Örebro University,Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Åman, Per (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Molekylära vetenskaper,Department of Molecular Sciences,Sveriges lantbruksuniversitet (SLU),Swedish University of Agricultural Sciences (SLU),Swedish University of Agricultural Sciences, Department of Molecular Sciences, Box, 7015, Uppsala, Sweden.
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- Landberg, Rikard, 1981 (författare)
- Umeå universitet,Näringsforskning,Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden; Department of Biology and Biological Engineering, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.
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(creator_code:org_t)
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- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Clinical Nutrition. - : Elsevier BV. - 1532-1983 .- 0261-5614. ; 39:1, s. 159-165
- Relaterad länk:
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https://doi.org/10.1...
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https://research.cha...
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https://res.slu.se/i...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background & aims: Rye consumption has shown beneficial effects on prostate cancer tumors, as indicated by slower initial tumor growth in animal models and lowering of prostate-specific antigen (PSA) in humans. This study evaluated the effects of whole grain/bran rye consumption on low-grade inflammation and endothelial function biomarkers in men with prostate cancer. Methods: Seventeen men with untreated, low-grade prostate cancer consumed 485 g rye whole grain and bran products (RP) per day or refined wheat products with added cellulose (WP) in a randomized crossover design. Fasting blood samples were taken before and after 2, 4, and 6 weeks of treatment. Results: Concentrations of tumor nuclear factor-receptor 2 (TNF-R2), e-selectin, and endostatin were significantly lower after consumption of the RP diet compared with WP (p < 0.05). Cathepsin S concentration was positively correlated to TNF-R2 and endostatin concentrations across all occasions. Strong correlations were consistently found between intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and between interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1RA). No effect of intervention was found in 92 inflammation-related protein biomarkers measured in a proximity extension assay. Conclusions: RP diet lowered TNF-R2, e-selectin, and endostatin, compared with WP in men with prostate cancer. These effects were accompanied by a reduction in PSA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Prostate cancer
- Low-grade inflammatory markers
- Endothelial function markers
- Whole grain/bran rye
- Refined wheat
- Plasma
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Zamaratskaia, Ga ...
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Mhd Omar, Nor Ad ...
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Brunius, Carl, 1 ...
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Hallmans, Göran, ...
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Johansson, Jan E ...
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Andersson, Sven ...
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Larsson, Anders
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Åman, Per
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Landberg, Rikard ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Läkemedelskemi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Clinical Nutriti ...
- Av lärosätet
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Chalmers tekniska högskola
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Sveriges Lantbruksuniversitet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet