| 1. |
- Hallberg, Lillemor R-M, 1942, et al.
(author)
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Psychometric evaluation of a Swedish version of the communication strategies scale of the communication profile for the hearing impaired.
- 1992
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In: Journal of speech and hearing research. - 0022-4685. ; 35:3, s. 666-74
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Journal article (peer-reviewed)abstract
- The Communication Strategies scale of the Communication Profile for the Hearing Impaired (CPHI) was translated into Swedish and used in several studies of people with hearing impairment (Hallberg & Carlsson, in press; Hallberg, Erlandsson, & Carlsson, 1991). In this study the scale was evaluated in terms of descriptive statistics, corrected item-total correlations, principal component analysis, and internal consistency reliability. Agreement with results from American studies is surprisingly good. Normative data based on three samples are presented: a general Swedish hearing-impaired sample with predominantly sensorineural hearing loss (N = 199), a subgroup of 105 younger subjects with noise-induced hearing loss, and a subgroup of 39 older subjects with sensorineural hearing loss due to heredity and/or old age. A significantly more frequent use of maladaptive behaviors (p less than .001) and verbal communication strategies (p less than .01) was reported by older subjects with age-related and/or hereditary hearing loss than by younger subjects with noise-induced hearing loss. The Communication Strategies scale seems to be an adequately reliable and clinically useful instrument for assessing adaptive and maladaptive strategies in hearing-impaired subjects.
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| 2. |
- Hansson, Kristina, et al.
(author)
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Grammatical Characteristics Of Swedish Children With Sli
- 1995
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In: Journal of Speech and Hearing Research. - 0022-4685. ; 38:3, s. 589-598
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Journal article (peer-reviewed)abstract
- Spontaneous speech samples from 10 Swedish children were collected and analyzed grammatically. The subjects consisted of 5 children with SLI and 5 MLU matched controls with normal grammatical development. The children with SLI differed significantly from the controls in their more restricted usage of word order patterns and in number of grammatical errors. As in studies on English-speaking children with SLI, the Swedish children with SLI had a large number of omissions of grammatical morphemes. Verb-related errors were more common than noun-related errors. Contrary to reports on children with SLI acquiring other languages, however, word order errors were also very common in the Swedish children with SLI. A restricted usage of word order patterns in combination with errors of word order indicates that not only morphological deficits but also syntactic difficulties can be found in children with SLI relative to MLU controls, depending on the target language. The findings show the importance of cross-linguistic comparisons of children with SLI.
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| 3. |
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| 4. |
- Hygge, Staffan, et al.
(author)
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Normal-hearing and hearing-impaired subjects' ability to just follow conversation in competing speech, reversed speech, and noise backgrounds
- 1992
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In: Journal of Speech and Hearing Research. - 0022-4685. ; 35:1, s. 208-15
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Journal article (other academic/artistic)abstract
- The performance on a conversation-following task by 24 hearing-impaired persons was compared with that of 24 matched controls with normal hearing in the presence of three background noises: (a) speech-spectrum random noise, (b) a male voice, and (c) the male voice played in reverse. The subjects' task was to readjust the sound level of a female voice (signal), every time the signal voice was attenuated, to the subjective level at which it was just possible to understand what was being said. To assess the benefit of lipreading, half of the material was presented audiovisually and half auditorily only. It was predicted that background speech would have a greater masking effect than reversed speech, which would in turn have a lesser masking effect than random noise. It was predicted that hearing-impaired subjects would perform more poorly than the normal-hearing controls in a background of speech. The influence of lipreading was expected to be constant across groups and conditions. The results showed that the hearing-impaired subjects were equally affected by the three background noises and that normal-hearing persons were less affected by the background speech than by noise. The performance of the normal-hearing persons was superior to that of the hearing-impaired subjects. The prediction about lipreading was confirmed. The results were explained in terms of the reduced temporal resolution by the hearing-impaired subjects.
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| 5. |
- Johansson, Ann-Sofie, et al.
(author)
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Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105
- 1998
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In: Journal of Molecular Cell Biology. - : Elsevier BV. - 1674-2788 .- 1759-4685 .- 0022-2836. ; 278:3, s. 687-698
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Journal article (peer-reviewed)abstract
- Human glutathione transferase P1-1 (GSTP1-1) is polymorphic in amino acid residue 105, positioned in the substrate binding H-site. To elucidate the role of this residue an extensive characterization of GSTP1-1/Ile105 and GSTP1-1/Val105 was performed. Mutant enzymes with altered volume and hydrophobicity of residue 105, GSTP1-1/Ala105 and GSTP1-1/Trp105, were constructed and included in the study. Steady-state kinetic parameters and specific activities were determined using a panel of electrophilic substrates, with the aim of covering different types of reaction mechanisms. Analysis of the steady-state kinetic parameters indicates that the effect of the substitution of the amino acid in position 105 is highly dependent on substrate used. When 1-chloro-2,4-dinitrobenzene was used as substrate a change in the side-chain of residue 105 seemed primarily to cause changes in the KM value, while the kcat value was not distinctively affected. With other substrates, such as 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole and ethacrynic acid both kcat and KM values were altered by the substitution of amino acid 105. The constant for formation of the sigma-complex between 1,3, 5-trinitrobenzene and glutathione was shown to be dependent upon the volume of the amino acid in position 105. The nature of the amino acid in position 105 was also shown to affect the thermal stability of the enzyme at 50 degrees C, indicating an important role for this residue in the stabilization of the enzyme. The GSTP1-1/Ile105 variant was approximately two to three times more stable than the Val105 variant as judged by their half-lives. The presence of glutathione in the incubation buffer afforded a threefold increase in the half-lives of the enzymes. Thus, the thermal stability of the enzyme and depending on substrate, both KM values and turnover numbers are influenced by substitutions in position 105 of GSTP1-1.
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| 8. |
- Schäfer, Karsten, et al.
(author)
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X-ray structures of the maltose-maltodextrin binding protein of the thermoacidophilic bacterium Alicyclobacillus acidocaldarius provide insight into acid stability of proteins
- 2004
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In: Journal of Molecular Cell Biology. - : Elsevier BV. - 1674-2788 .- 1759-4685 .- 0022-2836. ; 335:1, s. 261-274
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Journal article (peer-reviewed)abstract
- Maltose-binding proteins act as primary receptors in bacterial transport and chemotaxis systems. We report here crystal structures of the thermoacidostable maltose-binding protein from Alicyclobacillus acidocaldarius, and explore its modes of binding to maltose and maltotriose. Further, comparison with the structures of related proteins from Escherichia coli (a mesophile), and two hyperthermophiles (Pyrococcus furiosus and Thermococcus litoralis) allows an investigation of the basis of thermo- and acidostability in this family of proteins.The thermoacidophilic protein has fewer charged residues than the other three structures, which is compensated by an increase in the number of polar residues. Although the content of acidic and basic residues is approximately equal, more basic residues are exposed on its surface whereas most acidic residues are buried in the interior. As a consequence, this protein has a highly positive surface charge. Fewer salt bridges are buried than in the other MBP structures, but the number exposed on its surface does not appear to be unusual. These features appear to be correlated with the acidostability of the A. acidocaldarius protein rather than its thermostability. An analysis of cavities within the proteins shows that the extremophile proteins are more closely packed than the mesophilic one. Proline content is slightly higher in the hyperthermophiles and thermoacidophiles than in mesophiles, and this amino acid is more common at the second position of beta-turns, properties that are also probably related to thermostability. Secondary structural content does not vary greatly in the different structures, and so is not a contributing factor.
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| 9. |
- Ternström, Sten, 1956-, et al.
(author)
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Articulatory Fo perturbations and auditory feedback
- 1988
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In: Journal of speech and hearing research. - ASHA : American Speech Language Hearing Association. - 0022-4685. ; 31:2, s. 187-192
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Journal article (peer-reviewed)abstract
- Singers are required to sing with a high degree of precision of fundamental frequency (Fo). Does this mean that they have learned to compensate for the change of pitch that has been described in speech during production of different vowels? Experienced choir singers sang sustained tones with a change of vowel in mid-tone. The fundamental frequency was measured, and the resulting Fo contours were evaluated with respect to Fo effects coincident with the vowel changes. The tasks were performed both with normal auditory feedback and with the auditory feedback masked by noise in headphones. The vowels (i) and (y) were found to be associated with higher Fo than other vowels. The irregularities in the Fo curves were somewhat larger in the absence of auditory feedback. This is consistent with findings during speech production. The instability in Fo, measured as the standard deviation over each tone, was also larger in the absence of feedback.
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