| 1. |
- Antzutkin, Oleg, et al.
(author)
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Hydrogen bonding in Alzheimer’s amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy
- 2012
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In: Angewandte Chemie. - : Wiley. - 0044-8249. ; 124:41, s. 10435-10438
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Journal article (peer-reviewed)abstract
- Nach selektiver Markierung mit 17O und 15N wurden mithilfe von 15N{17O}-REAPDOR-NMR-Spektroskopie intermolekulare C17O⋅⋅⋅H15N-Wasserstoffbrücken in Ac-Aβ(16–22)-NH2- (siehe Schema) und Aβ(11–25)-Amyloidfibrillen untersucht, die mit der Alzheimer-Krankheit in Verbindung gebracht werden. Die Methode, die eine Bestätigung für die Struktur dieser Fibrillen lieferte, könnte auch im Zusammenhang mit anderen biologischen Proben nützlich sein.
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| 2. |
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| 3. |
- Cousins, David L., et al.
(author)
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Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis
- 2021
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 133:17, s. 9498-9501
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Journal article (peer-reviewed)abstract
- We report a novel and general method to access a highly under‐studied privileged scaffold – pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chemistry is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C‐B bond when suitably activated.
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| 4. |
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| 5. |
- Goesten, Maarten, et al.
(author)
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Cesium's off-the-map valence orbital
- 2017
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In: Angewandte Chemie. - : Wiley. - 1521-3773 .- 1433-7851 .- 0044-8249 .- 1521-3757.
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Journal article (peer-reviewed)abstract
- The Td-symmetric [CsO4]+ ion, featuring Cs in an oxidation state of 9, is computed to be a minimum. Cs uses outer core 5s and 5p orbitals to bind the oxygens. The valence Cs 6s orbital lies too high to be involved in bonding, and contributes to Rydberg levels only. From a Molecular Orbital perspective, the bonding scheme reminds of XeO4: an octet of electrons to bind electronegative ligands, and no low-lying acceptor orbitals on the central atom. In this sense, Cs+ resembles hypervalent Xe.
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| 6. |
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| 7. |
- Jönsson, Håkan, 1979-, et al.
(author)
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Tröpfchen-Mikrofluidik für die Einzelzellanalyse
- 2012
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In: Angewandte Chemie. - : Wiley Online Library. - 0044-8249 .- 1521-3757. ; 124:49, s. 12342-12359
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Journal article (peer-reviewed)abstract
- Die tröpfchenbasierte Mikrofluidik dient der Isolierung und Manipulation von einzelnen Zellen und Reagentien innerhalb von monodispersen, pikolitergroßen Flüssigkapseln bei einem Umsatz von tausenden Tröpfchen pro Sekunde. Diese Qualitäten machen die Tröpfchen‐Mikrofluidik geeignet für viele Anforderungen der Einzelzellanalyse. Durch die Monodispersität lässt sich die Konzentration in den Tröpfchen quantitativ einstellen. Die Tröpfchen bieten der Zelle und ihrer unmittelbaren Umgebung ein isoliertes Kompartiment, und bei einem Durchsatz von tausenden Tröpfchen pro Sekunde ist es möglich, zehntausende bis millionen verkapselte Zellen zu prozessieren. Heterogene Zellpopulationen lassen sich somit exakt beschreiben oder seltene Zellarten identifizieren. Das kleine Volumen der Tröpfchen macht auch sehr große Screenings ökonomisch machbar. Dieser Aufsatz gibt einen Überblick über den aktuellen Stand der Einzelzellanalyse durch die Tröpfchen‐Mikrofluidik und nennt Beispiele, bei denen sie biologische Vorgänge besser verstehen hilft.
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| 8. |
- Kao, Kun‐Che, et al.
(author)
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A General Approach for Monolayer Adsorption of High Weight Loadings of Uniform Nanocrystals on Oxide Supports
- 2021
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In: Angewandte Chemie. - : Wiley-Blackwell Publishing Inc.. - 0044-8249 .- 1521-3757. ; 133:14, s. 8050-8058
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Journal article (peer-reviewed)abstract
- Monodispersed metal and semiconductor nanocrystals have attracted great attention in fundamental and applied research due to their tunable size, morphology, and well-defined chemical composition. Utilizing these nanocrystals in a controllable way is highly desirable especially when using them as building blocks for the preparation of nanostructured materials. Their deposition onto oxide materials provide them with wide applicability in many areas, including catalysis. However, so far deposition methods are limited and do not provide control to achieve high particle loadings. This study demonstrates a general approach for the deposition of hydrophobic ligand-stabilized nanocrystals on hydrophilic oxide supports without ligand-exchange. Surface functionalization of the supports with primary amine groups either using an organosilane ((3-aminopropyl)trimethoxysilane) or bonding with aminoalcohols (3-amino-1,2-propanediol) were found to significantly improve the interaction between nanocrystals and supports achieving high loadings (>10 wt. %). The bonding method with aminoalcohols guarantees the opportunity to remove the binding molecules thus allowing clean metal/oxide materials to be obtained, which is of great importance in the preparation of supported nanocrystals for heterogeneous catalysis.
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| 9. |
- Karlsmo, Martin, 1995, et al.
(author)
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High‐performant all‐organic aqueous sodium‐ion batteries enabled by PTCDA electrodes and a hybrid Na/Mg electrolyte
- 2021
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In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 60:46, s. 24709-24715
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Journal article (peer-reviewed)abstract
- Aqueous sodium-ion batteries (ASIBs) are aspiring candidates for low environmental impact energy storage, especially when using organic electrodes. In this respect, perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) is a promising anode active material, but it suffers from extensive dissolution in conventional aqueous electrolytes. As a remedy, we here present a novel aqueous electrolyte, which inhibits the PTCDA dissolution and enables their use as all-organic ASIB anodes with high capacity retention and Coulombic efficiencies. Furthermore, the electrolyte is based on two, hence “hybrid”, inexpensive and non-fluorinated Na/Mg-salts, it displays favourable physico-chemical properties and an electrochemical stability window >3 V without resorting to the extreme salt concentrations of water-in-salt electrolytes. Altogether, this paves the way for ASIBs with both relatively high energy densities, inexpensive total cell chemistries, long-term sustainability, and improved safety.
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| 10. |
- Lendel, Christofer, et al.
(author)
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A Hexameric Peptide Barrel as Building Block of Amyloid-β Protofibrils
- 2014
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In: Angewandte Chemie. - : Wiley. - 0044-8249 .- 1521-3757. ; 126:47, s. 12970-12974
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Journal article (peer-reviewed)abstract
- Oligomeric and protofibrillar aggregates formed by the amyloid-β peptide (Aβ) are believed to be involved in the pathology of Alzheimer’s disease. Central to Alzheimer pathology is also the fact that the longer Aβ42 peptide is more prone to aggregation than the more prevalent Aβ40. Detailed structural studies of Aβ oligomers and protofibrils have been impeded by aggregate heterogeneity and instability. We previously engineered a variant of Aβ that forms stable protofibrils and here we use solid-state NMR spectroscopy and molecular modeling to derive a structural model of these. NMR data are consistent with packing of residues 16 to 42 of Aβ protomers into hexameric barrel-like oligomers within the protofibril. The core of the oligomers consists of all residues of the central and C-terminal hydrophobic regions of Aβ, and hairpin loops extend from the core. The model accounts for why Aβ42 forms oligomers and protofibrils more easily than Aβ40.
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