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  • Wennerberg, Johan, et al. (author)
  • A practical and environmentally friendly protocol for synthesis of α-deuterated carboxylic acids
  • 2023
  • In: Journal of Labelled Compounds and Radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 66:4-6, s. 138-144
  • Journal article (peer-reviewed)abstract
    • α-deuterated carboxylic acids have been synthesized from the corresponding malonic acids via hydrogen/deuterium exchange and decarboxylation in presence of D2O. The method is general, mild and efficient and does not require organic solvents or other additives. Yields range between 83% and 94% and purification was not necessary. Starting materials were easy accessible and the α-deuterated carboxylic acids may easily be transformed to other labeled compounds such as alcohols, aldehydes, esters, and amides. Characterization with NMR confirmed purity and isotopic purity.
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