| 1. |
- Anniko, Matti, et al.
(author)
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Cytoskeletal proteins in human hair cells
- 1995
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In: Acta oto-laryngologica. Supplementum. - 0365-5237 .- 1651-2464. ; 519, s. 8-12
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Journal article (peer-reviewed)abstract
- Human cochlear and vestibular hair cells (HCs) were analysed for the three major cytoskeletal types of structures: microfilaments, microtubules, and intermediate filaments and several of their associated proteins. Specific immunomorphological features were identified: the apical surface, the infracuticular rod of F-actin, the cytoplasm and the HC bases and their interactions with adjacent supporting cells. There is morphological evidence for at least three functionally interacting units: the OHC as a cytoskeletal string interacting with the Deiter's cell, being a part of the rigid pancellular protein shell of the organ of Corti; compartmentalization of HCs (surrounded by rigid intermediate filament proteins in the supporting cells); and a calcium-guided short-loop feed-back control of type I HCs. The cytoskeletal composition of all four types of human HCs and their adjacent structures is similar to, although not identical with, corresponding compositions in other mammalian species.
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| 2. |
- Anniko, Matti, et al.
(author)
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Protein patterns in human vestibular ganglion cells and hair cells, with functional interpretations
- 1993
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In: Acta oto-laryngologica. Supplementum. - 0365-5237. ; 503, s. 136-142
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Journal article (peer-reviewed)abstract
- Cytoskeletal organization was analysed in the vestibular ganglion cells and in the sensory epithelia of all five vestibular organs of the adult human temporal bone. A pancellular rigidity of the upper surfaces of the vestibular organs, evidenced by large quantities of intermediate filaments and actin, seems of importance for the mechanoelectrical transduction by opposing the motion of the cupulae and statoconial layers. Immunostaining for the calcium-binding protein synaptophysin in the sensory hair bundles and in the area close to the cuticular plates--the first of its kind to be demonstrated in human vestibular organs--indicates the presence of calcium-dependent ionic channels. The hypothesis is presented that the calyx might be involved in a short-loop feed back control of type I hair cells, i.e. of the mechanoelectrical transduction itself. Subpopulations of vestibular ganglion cells were identified by the staining pattern of cytoskeletal proteins, but not by ordinary ultrastructural analysis.
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| 3. |
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| 4. |
- Ekberg, Olle
(author)
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Diagnostic aspects of dysphagia
- 2000
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In: Acta Oto-Laryngologica. Supplement. - : Informa UK Limited. - 0365-5237 .- 0001-6489 .- 1651-2251. ; :Suppl. 543, s. 225-228
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Journal article (peer-reviewed)abstract
- Swallowing problems are common, with a prevalence of 5-30% in different populations. Clinical work-up must start with a careful evaluation of the symptomatology, which should then lead to appropriate investigations. A crucial point in the evaluation of these patients is the comparison between the patient's symptoms and the findings during the examination. Symptoms and findings often do not match, or incidental endoscopic or manometric findings are taken as an indication for treatment. This review tries to elucidate this relationship.
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| 5. |
- Enbom, Håkan, et al.
(author)
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Presentation of a posturographic test with loading of the proprioceptive system
- 1988
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In: Acta Oto-Laryngologica, Supplement. - 0365-5237. ; 455, s. 58-61
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Journal article (other academic/artistic)abstract
- Postural control is maintained by sensory feedback from visual, vestibular and somatosensory receptors. Recently several methods for evaluating postural control have been devised, utilizing an imposed perturbation. Most of these methods use stimuli which simultaneously affect more than one of the sensory feedback loops. In the present paper a posturographic technique is presented with specific loading of the proprioceptive system, using a computer controlled vibratory stimulus and computerized analysis of the results.
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| 6. |
- Hydén, Dag, et al.
(author)
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Broad frequency rotatory testing
- 1988
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In: Acta oto-laryngologica. Supplementum. - : Informa Healthcare. - 0365-5237 .- 1651-2464 .- 0001-6489 .- 1651-2251. ; 105:s455, s. 48-52
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Journal article (peer-reviewed)abstract
- The method of broad-frequency-band rotatory testing with results from normal subjects and patients with peripheral uni- and bilateral loss as well as central vestibular disorders are reviewed. The following conclusions are drawn: adequate testing of the vestibulo-ocular reflex including side detection of unilateral loss in light or in darkness can only be done with either random or high-frequency (2.5–3 Hz) sinusoidal stimulation. Measurements of compensatory eye movements at lower frequencies where vestibular and non-vestibular signals interact are of interest for central vestibular diagnosis. A decreased ability to suppress vestibular nystagmus is not an uncommon finding in patients with large acoustic neuromas or pathology in the brainstem or cerebellum.
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| 7. |
- Hydén, Dag, et al.
(author)
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Quantification of compensatory eye movements in light and darkness
- 1984
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In: Acta oto-laryngologica. Supplementum. - : Informa Healthcare. - 0365-5237 .- 1651-2464 .- 0001-6489 .- 1651-2251. ; 96:s406, s. 209-211
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Journal article (peer-reviewed)abstract
- A broad frequency-band rotatory test has been used to quantify compensatory eye movements in 13 healthy subjects during light and darkness conditions. Eye movements were recorded by EOG. Head movements were recorded either by a potentiometer attached to the chair's axis of rotation or by an angular rate sensor attached to a bite-board. Gain and phase values between eye and head velocity were calculated. A systematic error in the higher frequency range is introduced in the results by assuming head movement equal to chair movement. Different instructions in the dark can alter the gain values at lower frequencies (up to 2 Hz) during sinusoidal stimulation. During pseudorandom stimulation no such differences can be obtained. During all test conditions with the rate sensor the gain values approach unity at about 3 Hz.
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| 8. |
- Hydén, Dag, et al.
(author)
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Visual suppression tests in acoustic neuroma patients
- 1989
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In: Acta oto-laryngologica. Supplementum. - : Informa UK Limited. - 0365-5237 .- 1651-2464 .- 0001-6489 .- 1651-2251. ; 108:s468, s. 349-351
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Journal article (peer-reviewed)abstract
- Fifty-five patients with a unilateral acoustic neuroma were investigated preoperatively with visual suppression tests during rotatory oscillation and caloric irrigation. During a sinusoidal oscillation, 29% of the patients showed a reduced suppression compared to 9% during pseudo-random oscillation and 11 % in the caloric test. In the sinusoidal and caloric tests the majority of the patients with deficient suppression had large or medium-sized tumors. In a few patients with small tumors, pathology was observed in both sinusoidal and randomized tests, presumably as a sign of unconcentration. The study shows that the sinusoidal visual suppression test and to a lesser degree suppression during caloric irrigation are of value for identification of brainstem-cerebellum compression of acoustic neuromas.
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| 10. |
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