SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "L773:1097 4180 "

Search: L773:1097 4180

  • Result 1-10 of 109
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Bernink, JH, et al. (author)
  • Human ILC1: To Be or Not to Be
  • 2017
  • In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 46:5, s. 756-757
  • Journal article (other academic/artistic)
  •  
10.
  • Biram, Adi, et al. (author)
  • Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation.
  • 2022
  • In: Immunity. - : Elsevier BV. - 1097-4180 .- 1074-7613. ; 55:3
  • Journal article (peer-reviewed)abstract
    • Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response elicited against primary invading pathogens. We demonstrated that recruitment of Sca-1+ monocytes into lymphoid organs during Salmonella Typhimurium (STm) infection disrupted pre-existing germinal center (GC) reactions. GC responses induced by influenza, plasmodium, or commensals deteriorated following STm infection. GC disruption was independent of the direct bacterial interactions with B cells and instead was induced through recruitment of CCR2-dependent Sca-1+ monocytes into the lymphoid organs. GC collapse was associated with impaired cellular respiration and was dependent on TNFα and IFNγ, the latter of which was essential for Sca-1+ monocyte differentiation. Monocyte recruitment and GC disruption also occurred during LPS-supplemented vaccination and Listeria monocytogenes infection. Thus, systemic activation of the innate immune response upon severe bacterial infection is induced at the expense of antibody-mediated immunity.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 109

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view