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- Giraud, A, et al.
(author)
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The rise and fall of mutator bacteria.
- 2001
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In: Current Opinion in Microbiology. - 1369-5274 .- 1879-0364. ; 4:5, s. 582-5
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Journal article (peer-reviewed)abstract
- Bacteria with elevated mutation rates are frequently found among natural isolates. This is probably because of their ability to generate genetic variability, the substrate for natural selection. However, such high mutation rates can lead to the loss of vital functions. The evolution of bacterial populations may happen through alternating periods of high and low mutation rates. The cost and benefits of high mutation rates in the course of bacterial adaptive evolution are reviewed.
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- Achcar, F., et al.
(author)
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Trypanosoma brucei: meet the system
- 2014
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In: Current Opinion in Microbiology. - : Elsevier BV. - 1369-5274 .- 1879-0364. ; 20, s. 162-169
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Research review (peer-reviewed)abstract
- African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations for a variety of enzymes. Systems biology has arisen partly to allow contextualization of the massive datasets that describe individual chemical parts of biological systems. Here we describe recent efforts to collect and analyse data pertaining to all aspects of the trypanosome's biochemical physiology that go some way to describing the parasite as an integrated system.
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- Anjum, Muna F, et al.
(author)
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The potential of using E. coli as an indicator for the surveillance of antimicrobial resistance (AMR) in the environment
- 2021
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In: Current Opinion in Microbiology. - : Elsevier. - 1369-5274 .- 1879-0364. ; 64, s. 152-158
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Research review (peer-reviewed)abstract
- To understand the dynamics of antimicrobial resistance (AMR), in a One-Health perspective, surveillance play an important role. Monitoring systems already exist in the human health and livestock sectors, but there are no environmental monitoring programs. Therefore there is an urgent need to initiate environmental AMR monitoring programs nationally and globally, which will complement existing systems in different sectors. However, environmental programs should not only identify anthropogenic influences and levels of AMR, but they should also allow for identification of transmissions to and from human and animal populations. In the current review we therefore propose using antimicrobial resistant Escherichia coli as indicators for monitoring occurrence and levels of AMR in the environment, including wildlife.
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- Bernander, Rolf, et al.
(author)
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FtsZ-less cell division in archaea and bacteria
- 2010
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In: Current Opinion in Microbiology. - : Elsevier BV. - 1369-5274 .- 1879-0364. ; 13:6, s. 747-752
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Journal article (peer-reviewed)abstract
- A dedicated cell division machinery is needed for efficient proliferation of an organism. The eukaryotic actin-myosin based mechanism and the bacterial FtsZ-dependent machinery have both been characterized in detail, and a third division mechanism, the Cdv system, was recently discovered in archaea from the Crenarchaeota phylum. Despite these findings, division mechanisms remain to be identified in, for example, organisms belonging to the bacterial PVC superphylum, bacteria with extremely reduced genomes, wall-less archaea and bacteria, and in archaea that carry out the division process without cell constriction. Cytokinesis mechanisms in these clades and individual taxa are likely to include adaptation of host functions to division of bacterial symbionts, transfer of bacterial division genes into the host genome, vesicle formation without a dedicated constriction machinery, cross-wall formation without invagination, as well as entirely novel division mechanisms.
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