| 1. |
- Abdalla Omer, Hemn, et al.
(författare)
-
The role of inflammatory and remodelling biomarkers in patients with non-small cell lung cancer
- 2023
-
Ingår i: Central European Journal of Immunology. - : Polish Society of Experimental and Clinical Immunology. - 1426-3912 .- 1644-4124. ; 48:4, s. 330-337
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction:Biomarkers play a crucial role in evaluating the prognosis, diagnosis, and monitoringof non-small cell lung cancer (NSCLC). The aim of this study was to compare the levels of inflammatoryand remodelling biomarkers among patients with NSCLC and healthy controls (HCs) and to investigatethe correlation between these biomarkers.Material and methods:Blood samples were taken from 93 NSCLC and 84 HCs. Each sample wasanalysed for the inflammatory biomarkers transforming growth factor β1 (TGF-β1), mothers againstdecapentaplegic homolog 2 (SMAD2) and the remodelling biomarkers Wingless-related integration site(Wnt3a) and β-catenin (CTNN-β1).Results:The patients with NSCLC had significantly higher levels of all the measured biomarkers.In the NSCLC patients, TGF-β1 correlated significantly with SMAD2 (r = 0.34, p = 0.0008), Wnt3a(r = 0.328, p = 0.0013), and CTNN-β1 levels (r = 0.30, p = 0.004). SMAD2 correlated significantlywith CTNN-β1 (r = 0.546, p = 0.0001) and Wnt3a (r = 0.598, p = 0.0001). CTNN-β1 level also correlated with the level of Wnt3a (r = 0.61, p = 0.0001). No correlation was found between biomarkersand symptom scores.Discussion:In this study, patients with NSCLC had higher inflammatory and remodelling biomarker levels than HCs. In the NSCLC, there were significant associations between inflammatory andremodelling biomarkers. This indicates that measuring biomarkers could be valuable in the workupof NSCLC patients.Conclusions:Our investigation showed that inflammatory and remodelling biomarkers might playa role in future immunologic response and pharmacologically targeted NSCLC therapy.
|
|
| 2. |
- Afram, Gabriel, et al.
(författare)
-
Higher response rates in patients with severe chronic skin graft-versus-host disease treated with extracorporeal photopheresis
- 2019
-
Ingår i: Central European Journal of Immunology. - : TERMEDIA PUBLISHING HOUSE LTD. - 1426-3912 .- 1644-4124. ; 44:1, s. 84-91
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: Different forms of graft-versus-host disease (GVHD) remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The prognosis for steroid-refractory chronic GVHD (cGVHD) remains poor. Our aim was to evaluate extracorporeal photopheresis (ECP) treatment in cGVHD patients with different organ involvement to detect subgroups of patients with the best response.Material and methods: Thirty-four patients who underwent HSCT and developed moderate (n = 7) or severe (n = 27) steroid-refractory or steroid-dependent cGVHD treated with ECP were included in the analysis. A matched cGVHD control patient group untreated with ECP was collected for comparison.Results: Compared to the control group and the stable/progressive disease (SD/PD) patients, individuals with complete/partial remission have higher overall survival and lower transplant-related mortality. Furthermore, patients with complete and partial remission (CR/PR) had significantly higher levels of albumin and platelets after ECP treatment compared to patients with stable or progressive cGVHD (SD/PD). Corticosteroid treatment and other immunosuppressive agents could successfully be tapered in the CR/PR group compared to the SD/PD patients. In this study patients with skin cGVHD are those with the highest rate of CR/PR after ECP treatment.Conclusions: Our results suggest that ECP treatment is safe and effective for patients with predominantly skin, oral and liver cGVHD.
|
|
| 3. |
- Ali, Kosar M., et al.
(författare)
-
Biomarkers of type 2 and non-type 2 inflammation in asthma exacerbations
- 2024
-
Ingår i: Central European Journal of Immunology. - : Termedia. - 1426-3912 .- 1644-4124. ; 49:2, s. 1-11
-
Tidskriftsartikel (refereegranskat)abstract
- Introduction: in adult-onset asthma, two major endotypes have been proposed: t2 with eosinophilia and non-t2 characterised by neutrophils and interleukin (il)-17. the objective of the study was to exam-ine the endotype marker profile in patients with severe asthma who were hospitalized for exacerbations, with a focus on differentiating between viral and non-viral triggers.Material and methods: Forty-nine patients with asthma, admitted for exacerbations, and 51 healthy controls (hCs) were recruited. We further categorized the exacerbated asthma patients into two groups: non-viral infected (n = 38) and viral infected (n = 11) groups. Blood was drawn and a nasopharyngeal swab taken at the time of admission and eosinophil numbers, eosinophil cationic protein (eCP), immuno- globulin e (ige), tryptase and viral infection were determined. additionally, levels of il-17, il-33 and il-31 were assessed.Results: the majority of patients had adult onset asthma (age of diagnosis, 42.8 ±16.1) with a du-ration of 7.7 ±10.8 years, 24.5% being atopic. Patients had higher levels of eosinophils, eCP and ige than healthy controls (eosinophils, p = 0.003; eCP and ige, p = 0.0001). immunohistochem-istry confirmed eosinophils as a source of eCP. tryptase (p = 0.0001), il-17 (p = 0.0005), il-31 (p = 0.0001) and il-33 (p = 0.0002) were also higher in patients than controls. eCP correlated with tryptase (r = 0.08, p = 0.62). il-17 showed the best correlation with other mediators, including eCP (r = 0.35, p = 0.24), tryptase (r = 0.69, p = 0.0001), ige (r = 0.50, p = 0.0001), il-33 (r = 0.95, p = 0.0001) and il-31 (r = 0.89, p = 0.0001). ige, il-17, and il-31 had a high auC when differentiating those with severe and non-severe asthma. the group with exacerbated viral infection showed elevated levels of serum il-17 and il-31 compared to the non-infected group.Conclusions: Patients with asthmatic exacerbations were found to have higher levels of both t2 and non-t2 inflammatory markers than healthy controls. in the study, levels of ige, il-17, and il-31 differentiated between patients with severe and non-severe asthma. the last two cytokines were also able to distinguish between exacerbated asthma caused by viral infection and exacerbated asthma caused by non-viral infection.
|
|
| 4. |
|
|
| 5. |
|
|
