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- Chattopadhyay, Subhayan, et al.
(author)
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Weaponized genomics : potential threats to international and human security
- 2024
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In: Nature reviews genetics. - 1471-0056 .- 1471-0064. ; 25:1-2
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Journal article (peer-reviewed)abstract
- Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussions on the risks of DNA technology being weaponized in international conflict. With today’s changing security environment, we argue that risk assessments must be broadened from genetically targeted weapons to a series of new domains.
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| 4. |
- Crosetto, N, et al.
(author)
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Spatially resolved transcriptomics and beyond
- 2015
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In: Nature reviews. Genetics. - : Springer Science and Business Media LLC. - 1471-0064 .- 1471-0056. ; 16:1, s. 57-66
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Research review (peer-reviewed)
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| 5. |
- Ellegren, Hans, et al.
(author)
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Determinants of genetic diversity
- 2016
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 17:7, s. 422-433
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Research review (peer-reviewed)abstract
- Genetic polymorphism varies among species and within genomes, and has important implications for the evolution and conservation of species. The determinants of this variation have been poorly understood, but population genomic data from a wide range of organisms now make it possible to delineate the underlying evolutionary processes, notably how variation in the effective population size (Ne) governs genetic diversity. Comparative population genomics is on its way to providing a solution to 'Lewontin's paradox' - the discrepancy between the many orders of magnitude of variation in population size and the much narrower distribution of diversity levels. It seems that linked selection plays an important part both in the overall genetic diversity of a species and in the variation in diversity within the genome. Genetic diversity also seems to be predictable from the life history of a species.
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- Ellegren, Hans
(author)
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Sex-chromosome evolution : recent progress and the influence of male and female heterogamety
- 2011
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 12:3, s. 157-166
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Research review (peer-reviewed)abstract
- It is now clear that sex chromosomes differ from autosomes in many aspects of genome biology, such as organization, gene content and gene expression. Moreover, sex linkage has numerous evolutionary genetic implications. Here, I provide a coherent overview of sex-chromosome evolution and function based on recent data. Heteromorphic sex chromosomes are almost as widespread across the animal and plant kingdoms as sexual reproduction itself and an accumulating body of genetic data reveals interesting similarities, as well as dissimilarities, between organisms with XY or ZW sex-determination systems. Therefore, I discuss how patterns and processes associated with sex linkage in male-and female-heterogametic systems offer a useful contrast in the study of sex-chromosome evolution.
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| 7. |
- Ellegren, Hans, et al.
(author)
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The evolution of sex-biased genes and sex-biased gene expression
- 2007
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 8:9, s. 689-698
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Research review (peer-reviewed)abstract
- Differences between males and females in the optimal phenotype that is favoured by selection can be resolved by the evolution of differential gene expression in the two sexes. Microarray experiments have shown that such sex-biased gene expression is widespread across organisms and genomes. Sex-biased genes show unusually rapid sequence evolution, are often labile in their pattern of expression, and are non-randomly distributed in the genome. Here we discuss the characteristics and expression of sex-biased genes, and the selective forces that shape this previously unappreciated source of phenotypic diversity. Sex-biased gene expression has implications beyond just evolutionary biology, including for medical genetics.
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- Forsberg, Joanna Stjernschantz, et al.
(author)
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A big step for Finnish biobanking
- 2014
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 15:1, s. 6-6
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Journal article (other academic/artistic)
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