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1.	Acharya, P, et al. (author) An energetic correlation of ab initio and NMR studies of the 3 '-gauche effect in 3 '-substituted thymidines 2001 In: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. - : MARCEL DEKKER INC. - 1525-7770. ; 20:4-7, s. 1229-1233 Journal article (peer-reviewed)abstract A straightforward correlation of our experimental NMR findings on 3'-substituted thymidine derivatives with that of the ab initio calculations shows that (i) the DeltaG(NRM)degrees (298k) of N reversible arrow S equilibrium in nucleoside can be predicted
2.	Acharya, P, et al. (author) Molecular modelling of 2 '-OH mediated hydrogen bonding in ribonucleos(t)ides by NMR constrained AM1 and MMX calculations 2001 In: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. - : MARCEL DEKKER INC. - 1525-7770. ; 20:4-7, s. 1211-1217 Journal article (peer-reviewed)abstract The intra- and intermolecular hydrogen bonding (DeltaG(298K)degrees approximate to 2 kcal mol(-1)) of 2'-OH in nucleos(t)ides has been reported by the temperature- and concentration-dependent NMR study in conjunction with dihedral dependence of the NMR de
3.	Adema, AD, et al. (author) Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells 2006 In: Nucleosides, nucleotides & nucleic acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 25:9-11, s. 981-986 Journal article (peer-reviewed)
4.	Almer, Sven (author) Novel Strategies in the Thiopurine Treatment of Inflammatory Bowel Disease 2010 In: Nucleosides, Nucleotides & Nucleic Acids. - : Taylor and Francis. - 1525-7770 .- 1532-2335. ; 29:04-Jun, s. 267-277 Journal article (peer-reviewed)abstract Thiopurine drugs are widely used as immunomodulatory and corticosteroid-sparing agents in inflammatory bowel disease. Despite being old drugs, a renewed research and clinical interest in their application has emerged during the last decade. The application of pharmacogenetic insights and metabolic monitoring, together with treatment strategies in combination with anti-TNF-antibodies and possibilities to modulate their metabolism, has paved the way to a omoderno use of the thiopurines. These aspects are briefly overviewed herein.
5.	Andersen, Gorm, et al. (author) Catabolism of pyrimidines in yeast: A tool to understand degradation of anticancer drugs 2006 In: Nucleosides, Nucleotides & Nucleic Acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 25:9-11, s. 991-996 Journal article (peer-reviewed)abstract The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved in degradation of several chemotherapeutic drugs, such as 5-fluorouracil; it also is important in plants, unicellular eukaryotes, and bacteria for the degradation of pyrimidine-based biocides/antibiotics. During the last decade we have developed a yeast species, Saccharomyces kluyveri, as a model and tool to study the genes and enzymes of the pyrimidine catabolic pathway. In this report, we studied degradation of uracil and its putative degradation products in 38 yeasts and showed that this pathway was present in the ancient yeasts but was lost approximately 100 million years ago in the S. cerevisiae lineage.
6.	Astrom, H, et al. (author) A method for synthesis of an artificial ribonuclease 2001 In: Nucleosides, nucleotides & nucleic acids. - 1525-7770. ; 20:4-7, s. 1385-1388 Journal article (peer-reviewed)
7.	Bjerke, M, et al. (author) Alterations of mitochondrial DNA in CEM cells selected for resistance toward ddC toxicity 2006 In: Nucleosides, nucleotides & nucleic acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 25:9-11, s. 987-990 Journal article (peer-reviewed)
8.	Bjerke, M, et al. (author) Reduced levels of mitochondrial DNA increases the toxicity of 9-beta-D-arabinofuranosylguanine (araG) 2008 In: Nucleosides, nucleotides & nucleic acids. - : Informa UK Limited. - 1532-2335 .- 1525-7770. ; 27:6-76, s. 746-749 Journal article (peer-reviewed)
9.	Bjerke, M, et al. (author) Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts 2010 In: Nucleosides, nucleotides & nucleic acids. - : Informa UK Limited. - 1532-2335 .- 1525-7770. ; 29:1, s. 1-13 Journal article (peer-reviewed)
10.	Björnberg, Olof, et al. (author) Ribosylurea accumulates in yeast urc4 mutants 2010 In: Nucleosides, Nucleotides & Nucleic Acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 29:4-6, s. 433-437 Journal article (peer-reviewed)abstract Yeast Saccharomyces (Lachancea) kluyveri urc4 mutants, unable to grow on uracil, biotransformed (14)C(2)-uracil into two labeled compounds, as detected by high performance liquid chromatography (HPLC). These two compounds could also be obtained following organic synthesis of ribosylurea. This finding demonstrates that in the URC pyrimidine degradation pathway, the opening of the uracil ring takes place when uracil is attached to the ribose moiety. Ribosylurea has not been reported in the cell metabolism before and the two observed compounds likely represent an equilibrium mixture of the pyranosyl and furanosyl forms.

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Result 1-10 of 87

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Type of publication: journal article (86); other publication (1)

Type of content: peer-reviewed (84); other academic/artistic (3)

Author/Editor: Stromberg, R (15); Eriksson, Staffan (14); Piskur, Jure (13); Karlsson, A. (7); Johansson, M (5); Acharya, P (3); show more...; Chattopadhyaya, J (3); Pejler, Gunnar (3); Solaroli, N (3); Chattopadhyaya, Jyot ... (2); Trifonova, A (2); Foldesi, A (2); Sigurdsson, S (2); Albertioni, Freidoun (2); Almer, Sven (2); Wang, X. (1); Franco, M. (1); Acharya, S (1); Landerholm, Kalle (1); Grey, Carl (1); Söderberg, Linda (1); D'Amato, M (1); Thibaudeau, C (1); Velikian, I (1); Adema, AD (1); Zuurbier, L (1); Floor, K (1); Hubeek, I (1); Kaspers, GJL (1); Albertoni, F (1); Peters, GJ (1); Ekström, Simon (1); Adlercreutz, Patrick (1); Smith, CIE (1); Söderkvist, Peter, 1 ... (1); Eriksson, S. (1); Nyrén, Pål (1); Gharizadeh, B. (1); Rigler, R (1); Albertioni, F (1); Mirzaee, S (1); Andersen, G. (1); Shamoun, Levar (1); Wågsäter, Dick, Prof ... (1); Dimberg, Jan (1); Hindorf, Ulf (1); Almer, Sven, 1953- (1); Ström, Magnus, 1945- (1); Alvarez, R (1); Zamaratski, E (1); show less...

University: Karolinska Institutet (34); Lund University (21); Swedish University of Agricultural Sciences (17); Uppsala University (14); Linköping University (8); Stockholm University (4); show more...; Umeå University (3); Royal Institute of Technology (1); Jönköping University (1); show less...

Language: English (87)

Research subject (UKÄ/SCB): Natural sciences (34); Medical and Health Sciences (15); Agricultural Sciences (3); Engineering and Technology (1)

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