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Search: L773:1546 1726

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  • Aizman, O, et al. (author)
  • Anatomical and physiological evidence for D-1 and D-2 dopamine receptor colocalization in neostriatal neurons
  • 2000
  • In: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 3:3, s. 226-230
  • Journal article (peer-reviewed)abstract
    • Despite the importance of dopamine signaling, it remains unknown if the two major subclasses of dopamine receptors exist on the same or distinct populations of neurons. Here we used confocal microscopy to demonstrate that virtually all striatal neurons, both in vitro and in vivo, contained dopamine receptors of both classes. We also provide functional evidence for such colocalization: in essentially all neurons examined, fenoldopam, an agonist of the D-1 subclass of receptors, inhibited both the Na+/K+ pump and tetrodotoxin (TTX)-sensitive sodium channels, and quinpirole, an agonist of the Dr subclass of receptors, activated TTX-sensitive sodium channels. Thus D-1 and D-2 classes of ligands may functionally interact in virtually all dopamine-responsive neurons within the basal ganglia.
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  • Akbarian, S, et al. (author)
  • The PsychENCODE project
  • 2015
  • In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 18:12, s. 1707-1712
  • Journal article (peer-reviewed)
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  • Arenas, E (author)
  • Parkinson's disease in the single-cell era
  • 2022
  • In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 25:5, s. 536-538
  • Journal article (peer-reviewed)
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  • Barr, Gordon A, et al. (author)
  • Transitions in infant learning are modulated by dopamine in the amygdala
  • 2009
  • In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 12, s. 1367-1369
  • Journal article (peer-reviewed)abstract
    • Behavioral transitions characterize development. Young infant rats paradoxically prefer odors that are paired with shock, but older pups learn aversions. This transition is amygdala and corticosterone dependent. Using microarrays and microdialysis, we found downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone-injected 8-d-old pups and untreated 12-d-old pups learned aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions, whereas dopamine antagonism reinstated preference learning.
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  • Bartoletti, Alessandro, et al. (author)
  • Environmental enrichment prevents effects of dark-rearing in the rat visual cortex
  • 2004
  • In: Nature Neuroscience. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 7:3, s. 215-216
  • Journal article (peer-reviewed)abstract
    • Environmental enrichment potentiates neural plasticity, enhancing acquisition and consolidation of memory traces. In the sensory cortices, after cortical circuit maturation and sensory function acquisition are completed, neural plasticity declines and the critical period 'closes'. In the visual cortex, this process can be prevented by dark-rearing, and here we show that environmental enrichment can promote physiological maturation and consolidation of visual cortical connections in dark-reared rats, leading to critical period closure.
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