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| 2. |
- Alhassan, E., et al.
(författare)
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TENDL-based evaluation and adjustment of p+111Cd between 1 and 100 MeV
- 2023
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Ingår i: Applied Radiation and Isotopes. - : Elsevier. - 0969-8043 .- 1872-9800. ; 198
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Tidskriftsartikel (refereegranskat)abstract
- Proton induced reaction data are needed in the optimization of various radioisotope production routes, among others. In this work, the evaluation of proton-induced reactions on 111Cd between 1 and 100 MeV using the TALYS code system within an iterative Bayesian Monte Carlo (iBMC) framework, is presented. The method involves the simultaneous variation of a large number of nuclear reaction models included in the TALYS code system as well as their parameters. Each random TALYS calculation yields a vector of calculated values of cross section observables as well as the angular distributions, among others, which were compared with corresponding vectors of carefully selected differential experimental data for reaction channels where data were available. The random nuclear data file with the maximum likelihood function value obtained from combining the individual chi 2s computed for the considered reaction channels was chosen as the parent vector and the starting point for the generation of a further set of random TALYS calculations. This was repeated multiple times until a targeted convergence of 5% was reached. The final evaluated file was compared with available experimental data from the EXFOR database as well as with the evaluations from the TENDL-2021 and JENDL5.0 libraries, and found to compare favorably.
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| 4. |
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| 5. |
- Aneheim, Emma, 1982, et al.
(författare)
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N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides
- 2015
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 96, s. 1-5
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Tidskriftsartikel (refereegranskat)abstract
- In this work a new coupling reagent, N[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as I-125 and At-211, indicating potential use within targeted radiotherapy.
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| 6. |
- Bargholts, Christof, et al.
(författare)
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A new laboratory for measurements of low-level radioactivity
- 2008
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 66:10, s. 1443-1449
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Tidskriftsartikel (refereegranskat)abstract
- A laboratory for measuring low-level radioactivity has been built at the AlbaNova University Center in Stockholm. Low-level concrete in combination with a 5 cm iron lining provide an average photon fluency rate from terrestrial sources at least a factor of 40 below that in the common laboratories of the Center. The radon activity inside the laboratory has been measured to (3 +/- 2) Bq m(-3). Material considerations are discussed. Construction and performance of the laboratory, as well as the present instrumentation, is described.
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| 7. |
- Björke, Henrik, et al.
(författare)
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Automated, high-resolution cellular retention and uptake studies in vitro
- 2006
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 64:8, s. 901-905
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Tidskriftsartikel (refereegranskat)abstract
- This report describes an automated method for the measurements of cellular retention and uptake of radiolabeled proteins interacting with cell-surface receptors on intact cancer cells. A complete uptake and retention measurement was performed in one cell dish using a rotating radioimmunoassay (RIA) principle. Compared to common manual measurements, rotating RIA saved both labor time and reagents and provided real-time binding traces with superior time-resolution. The rotating RIA retention profiles for different interactions agreed with retention times reported in the literature.
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| 8. |
- Björke, Henrik, et al.
(författare)
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Measuring the affinity of a radioligand with its receptor using a rotating cell dish with in situ reference area
- 2006
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 64:1, s. 32-37
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Tidskriftsartikel (refereegranskat)abstract
- This report describes a semi-automated method for the measurement of affinity of radiolabeled ligands interacting with cell-surface receptors on intact cancer cells. The method saves labor time and reagents compared to common manual measurements. A complete affinity measurement can be performed in one cell dish by using a target cell area and a reference area and repeatedly measure the differential activity (i.e. target activity-reference activity). The affinities obtained for different ligand-receptor interactions agreed with affinities reported in the literature.
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| 9. |
- Champion, C., et al.
(författare)
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Dose point kernels in liquid water : An intra-comparison between GEANT4-DNA and a variety of Monte Carlo codes
- 2014
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 83, s. 137-141
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Tidskriftsartikel (refereegranskat)abstract
- Modeling the radio-induced effects in biological medium still requires accurate physics models to describe the interactions induced by all the charged particles present in the irradiated medium in detail. These interactions include inelastic as well as elastic processes. To check the accuracy of the very low energy models recently implemented into the GEANT4 toolkit for modeling the electron slowing-down in liquid water, the simulation of electron dose point kernels remains the preferential test. In this context, we here report normalized radial dose profiles, for mono-energetic point sources, computed in liquid water by using the very low energy GEANT4-DNA physics processes available in the GEANT4 toolkit. In the present study, we report an extensive intra-comparison of profiles obtained by a large selection of existing and well-documented Monte-Carlo codes, namely, EGSnrc, PENELOPE, CPA100, FLUKA and MCNPX.
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| 10. |
- Czub, Joanna, et al.
(författare)
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Biological effects of mixed-ion beams. Part 1 : Effect of irradiation of the CHO-K1 cells with a mixed-ion beam containing the carbon and oxygen ions
- 2018
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Ingår i: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043 .- 1872-9800. ; 139, s. 304-309
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Tidskriftsartikel (refereegranskat)abstract
- Carbon and oxygen ions were accelerated simultaneously to estimate the effect of irradiation of living cells with the two different ions. This mixed ion beam was used to irradiate the CHO-K1 cells, and a survival test was performed. The type of the effect of the mixed ion beam on the cells was determined with the isobologram method, whereby survival curves for irradiations with individual ion beams were also used. An additive effect of irradiation with the two ions was found.
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