| 1. |
- Aldawi, Nesreen, et al.
(author)
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Initial increase in glucose variability during Ramadan fasting in non-insulin-treated patients with diabetes type 2 using continuous glucose monitoring
- 2019
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In: Libyan Journal of Medicine. - : Informa UK Limited. - 1993-2820 .- 1819-6357. ; 14:1
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Journal article (peer-reviewed)abstract
- There are no studies evaluating the glucose variability in different periods of Ramadan fasting in patients with type 2 diabetes using continuous glucose monitoring (CGM). This study examined the effect of Ramadan fasting on interstitial glucose (IG) variability in early,- late-, and post-Ramadan compared to pre-Ramadan days in non-insulin-treated type 2 diabetes patients. Participants had a CGM system connected 2 or 3 days before Ramadan start, which was removed on the third or fourth day of Ramadan. CGM performance continued for a total of 6 days. A second CGM performance started on the 27th or 28th day of Ramadan and ended on the 4th or 5th post-Ramadan day. First, CGM recordings were divided into pre-Ramadan and early-Ramadan CGM, and second recordings into late-Ramadan and post-Ramadan. At each visit, blood pressure, body weight, and waist circumference were measured, and fasting blood samples were collected for HbA1c and plasma glucose. All patients received recommended Ramadan education before Ramadan. Thirty-three patients (mean age 55.0 ± 9.8 years, 73% males) were prospectively included. IG variability, estimated as mean amplitude of glycaemic excursions (MAGE), increased significantly in early-Ramadan compared to pre-Ramadan (P = 0.006) but not in late-Ramadan and post-Ramadan recording days. Only patients on >2 anti-diabetic drugs (n = 16, P = 0.019) and those on sulphonylureas (n = 14, P = 0.003) showed significant increase in MAGE in early-Ramadan. No significant changes were seen in coefficient of variation, time in range, time in hyperglycaemia, or time in hypoglycaemia. Except for an initial increase in glucose variability, fasting Ramadan for patients with non-insulin-treated type 2 diabetes did not cause any significant changes in glucose variability or time in hypoglycaemia during CGM recording days compared to non-fasting pre-Ramadan period.
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| 4. |
- Bendardaf, Riyad, et al.
(author)
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The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients
- 2017
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In: Libyan Journal of Medicine. - Abingdon, Oxfordshire, United Kingdom : Taylor & Francis. - 1993-2820 .- 1819-6357. ; 12:1
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Journal article (peer-reviewed)abstract
- Colorectal cancer is third leading cause of cancer mortality. About 60% of patients hadalready developed metastasis at the time of diagnosis. Vascular endothelial growth factor(VEGF) is crucial for the development of neovascularization and hence metastasis. This studyaimed at investigating the relation between the expression of VEGF in biopsies from surgically dissected colon cancer and the survival of those patients. Biopsies were collected from86 patients with advanced colon cancer and sections were stained by immunohistochemistryfor VEGF. Patients received chemotherapy after the operation and were followed up fordisease progression and survival. The clinical data were statistically analyzed with respectto the immunohistochemistry results. The survival of the patients was significantly longer inthe patients for whom biopsies showed negative or weak expression of VEGF in comparisonto those with moderate to high expression (p-value = 0.04). The expression of VEGF was morefrequent in the patients who died as a consequence of the disease in comparison to the 10-year survivors. In conclusion, VEGF could be related to the survival of the patients withcolorectal carcinoma and should be considered as a predictor of the prognosis.
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| 5. |
- Bredan, Amin, et al.
(author)
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COVID-19 epidemic in Libya
- 2021
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In: Libyan Journal of Medicine. - : Informa UK Limited. - 1993-2820 .- 1819-6357. ; 16:1
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Journal article (peer-reviewed)abstract
- The first case of COVID-19 was identified in Libya on 24/3/2020, and about 2 months later, the number of reported COVID-19 cases started to increase notably. The outbreak was first prominent in the southern region (Sabha) and then spread to the western and eastern parts of Libya. By 24/12/2020, the reported total number of deaths from COVID-19 reached 1415. There seems to be no published data on the size of the epidemic in Libya. Here, we estimated the number of Libyans exposed to COVID-19 by using a COVID-19 mortality adjusted mathematical model for the spread of infectious diseases. We estimated that 14–20% of the Libyan population have been exposed to the COVID-19 pandemic. Thus, the risk of spread of COVID-19 infections during the coming months is high, and a considerable number of Libyans, particularly the elderly and people with chronic diseases, should be protected against COVID-19 infection. This is particularly urgent in the light of unofficial reports that the relevant healthcare facilities are under extreme stress.
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| 8. |
- Eldin, Ghada Shiekh, et al.
(author)
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High prevalence rate of left superior vena cava determined by echocardiography in patients with congenital heart disease in Saudi Arabia
- 2013
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In: Libyan Journal of Medicine. - : Informa UK Limited. - 1993-2820 .- 1819-6357. ; 8
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Journal article (peer-reviewed)abstract
- Background: Persistent left superior vena cava (LSVC) is one of the common anomalies of the systemic veins. Its prevalence is 0.1-0.3% in the general population and is more common with congenital heart disease (CHD). The importance of detecting persistent LSVC prior to cardiac surgery is paramount for systemic veins cannulations. Aim: The aim was to evaluate the prevalence of persistent LSVC in patients with CHD in Saudi Arabia. Methods: All patients referred to our institution had echocardiography. All complete studies were reviewed for the presence of persistent LSVC. A computerized database was created including the demographic data, CHD diagnoses, and the presence of persistent LSVC. Results: A total of 2,042 were examined with an age range of 1 day to 16 years. The complete echocardiographic studies were 1,832 (90%) of whom 738 (40%) patients had CHD. The prevalence of persistent LSVC in patients with CHD was 7.8% (OR 9.26, 95% CI 4.7-18.2, p <0.001). The most common cardiac defect associated with persistent LSVC was complete atrioventricular septal defect (AVSD); all patients with AVSD had Down syndrome. The total number of patients with AVSD was 41, and persistent LSVC was found in 11 (26%) of them (odds ratio 5.1, 95% CI 2.4-10.8, p <0.001). Conclusions: The prevalence of persistent LSVC in the current population is almost double the reported prevalence obtained using the same echocardiographic screening tool.
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| 9. |
- Jadoon, Shehla, et al.
(author)
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Paediatricians' referral preference of patients with embolised intravascular foreign bodies: a survey-based study
- 2013
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In: Libyan Journal of Medicine. - : Informa UK Limited. - 1993-2820 .- 1819-6357. ; 8
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Journal article (peer-reviewed)abstract
- Background: Central line insertion is a routine procedure in medical practice. Dislodgement of lines into the vascular system is a rare complication. We noticed that paediatric health care providers (PHCP) contact the cardiac or general paediatric surgeon for extraction of dislodged lines more frequently than using the less invasive percutaneous approach. Aim: To study the referral preference of PHCP for patient with embolised intravascular foreign bodies. Methods: A questionnaire with three questions was distributed to PHCP of all paediatric subspecialties, including surgery, in two tertiary care centres. The questions were about the total number of patients seen with central line, experience with complications, and preferred specialty for removal of dislodged central lines. Results: The questionnaire was distributed to 128 professionals. The response rate was 79% (n = 101). Incomplete answers (n = 14) were excluded. The grades of responders were senior consultants 18%, junior consultants 38%, and residents 43%. Thirty nine percent of care providers experienced dislodgement or fragmentation of central lines. The majority (82%) prefer to refer the patients for surgical removal. Conclusions: Most PHCP in the selected hospitals prefer to refer patients with embolised foreign bodies in the vascular system for surgical removal. The local health policy should be updated for the use of the alternative percutaneous approach.
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| 10. |
- Mohamed, Nahla, et al.
(author)
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Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan
- 2019
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In: Libyan Journal of Medicine. - : Taylor & Francis. - 1993-2820 .- 1819-6357. ; 14:1
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Journal article (peer-reviewed)abstract
- Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Frequent unknown fever outbreaks have been reported in eastern region, Sudan. However, diagnosis was based exclusively on clinical signs and symptoms without confirmatory laboratory investigations. However, for accurate detection of these viruses in outbreaks, molecular technique is considered. The objective of this study was to determine the prevalence of six arboviruses in the Kassala state of east Sudan during unknown fever outbreak. A cross sectional hospital-based study was conducted in the Kassala, Teaching Hospital. Blood samples from 119 patients suffering from unknown fever were used for screening of six arboviruses, hepatitis E virus and malarial using molecular techniques and serology. The overall arboviruses seroprevelance was 61.3% (73/119). The highest positivity rate was 73.1% (52/73) chikungunya virus; 29 males and 20 females patients were chikungunya positive. Other arboviruses were circulating in low rate 20.5% (15/73), and 6.8% (5/73) for sindbis and rift valley fever viruses respectively. Hepatitis E virus was negative in all cases and malaria positivity rate 13.4% (16/119). The prevalence of arboviruses among unknown fever patients present to Kassala teaching hospital of eastern region in Sudan is significantly high (61.3%). The chikungunya virus is the predominant causative agent of arboviruses. Molecular techniques such as PCR are important for accurate and rapid diagnosis of this viral outbreak.
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