| 1. |
- Raza, Muhammad Liaquat, et al.
(author)
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Therapeutic Potential of Iridoid Derivatives: Patent Review.
- 2019
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In: Inventions. - : MDPI AG. - 2411-5134. ; 4:2
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Research review (peer-reviewed)abstract
- Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the potential to increase their effects. Additionally, future research should focus on the synthesis of halo analogs as well as preparing homo dimers or heterodimers of iridoids, since these might quite conceivably possess an increased bioactivity.
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| 2. |
- Svenner, A., et al.
(author)
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A simulator-based comparison of a novel 3d and a conventional 3d vision system-surgical performance and subjective ratings
- 2019
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In: Inventions. - : MDPI Multidisciplinary Digital Publishing Institute. - 2411-5134. ; 4:4
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Journal article (peer-reviewed)abstract
- In laparoscopy, novel three-dimensional laparoscopic vision systems (3D LVS) without glasses (3D−) have been invented. While standard 3D LVS with glasses (3D+) have shown advantages over original two-dimensional systems, quantitative comparisons of surgical performance between 3D− and 3D+ systems are still lacking. The aim is to compare the systems in simulated robotic surgery tasks. In a crossover study, 18 medical students performed four basic laparoscopic tasks in the validated Simball Box simulator with authentic surgical instruments by using the 3D+ and 3D− systems. Performance was measured by the number of errors and the task’s duration. Subjective ratings of perceptions and preference were assessed after each test. There were significant, but still minor, advantages for the conventional 3D+ system regarding spatial orientation and sense of depth. Overall, ten and eight subjects preferred 3D+ and 3D− systems, respectively. No significant differences were found in performance, post-operative physicals or eye symptoms. The novel 3D− system was similar to the conventional 3D+ system regarding performance and overall preference, while there were minor advantages for the 3D+ system in the subjective ratings. Since the 3D− system is a new invention, it should have a higher potential of usability improvements.
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| 3. |
- Mikhaltchouk, Inga, et al.
(author)
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Barriers and Facilitators for Usage of Self-Compacting Concrete—An Interview Study
- 2024
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In: Inventions. - : MDPI AG. - 2411-5134. ; 9:3
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Journal article (peer-reviewed)abstract
- Workers in the construction industry must endure different weather conditions, long working hours, and engage in repetitive and strenuous jobs with unrealistic deadlines. Sick leaves, caused by accidents and by work-related diseases, are common in the construction industry. Hand–arm vibration from hand-held power tools is a cause of significant ill health (disorders of the blood vessels, nerves, and joints). Self-compacting concrete (SCC) is a fluid concrete and does not need to be vibrated. Despite the health advantages of SCC, its market share in Sweden is lower than in comparable countries. The aim of this article is to describe views, opinions, and knowledge concerning the work environment and health in concrete casting and to identify barriers and facilitators of SCC usage. Semi-structured interviews were conducted with 24 interviewees from the construction industry in Sweden. The answers were analysed from a human–technology–organisation (HTO) perspective in order to identify barriers and facilitators for a broader usage of SCC. The results indicate that knowledge about SCC is low within the Swedish construction industry, including educational institutions; when SCC is chosen, it is chosen exclusively due to its technical characteristics, and not because it eliminates vibrations. Barriers to a broader usage of SCC comprise an incomplete knowledge base, clients who never choose it, recipes that are said to be too demanding, and workplace traditions. Facilitators comprise large companies investing in knowledge development about SCC and engaged persons promoting it. This study used an HTO-based model (BTOH) to identify barriers and facilitators for a broader usage of SCC, thus contributing to a deeper understanding of reasons for the low usage of SCC and ways of increasing it.
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