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- Nateghi Pettersson, Mehrdad, et al.
(author)
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High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
- 2019
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In: American journal of ophthalmology case reports. - : Elsevier. - 2451-9936. ; 15
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Journal article (peer-reviewed)abstract
- PurposeTo describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial presentation.ObservationsAn otherwise healthy 24-year old female presented with a severe unilateral keratitis. The diagnosis eluded clinicians for several months and when finally confirmed as AK, anti-amoebic therapy was instated and only appeared to be effective after addition of high fluence PACK-CXL.Conclusion and importanceIn this case of advanced AK, high fluence PACK-CXL treatment given adjuvant to pharmacologic anti-amoebic therapy resulted in lasting pain relief, re-epithelization and eradication of the Acanthamoeba parasite. Given adjuvant to anti-amoebic pharmacotherapy, high fluence PACK-CXL might be a useful method for treating typically refractory advanced AK.
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