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Träfflista för sökning "L773:9781627034319 OR L773:9781627034326 "

Search: L773:9781627034319 OR L773:9781627034326

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1.
  • Lagali, Neil, et al. (author)
  • In vivo confocal microscopy of the cornea to assess tissue regenerative response after biomaterial implantation in humans.
  • 2013
  • In: Corneal Regenerative Medicine. - Totowa, NJ : Humana Press. - 9781627034319 - 9781627034326 ; , s. 211-23
  • Book chapter (other academic/artistic)abstract
    • Laser-scanning in vivo confocal microscopy (IVCM) of the cornea is becoming an increasingly popular tool to examine the living human cornea with cellular-level detail in both healthy and pathologic states. Here, we describe the use of the IVCM technique to examine the processes of tissue healing and regeneration in the living human eye after biomaterial implantation. The regenerative response can be assessed by performing longitudinal IVCM imaging of a laboratory-made, cell-free biomaterial, after direct implantation into a pathologic eye as a primary alternative to human donor tissue transplantation.
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2.
  • Islam, Mohammad Mirazul, et al. (author)
  • Fabrication of a human recombinant collagen-based corneal substitute using carbodiimide chemistry
  • 2013
  • In: Methods in Molecular Biology. - Totowa, NJ : Humana Press. - 1064-3745 .- 1940-6029. - 9781627034319 ; 1014, s. 157-164
  • Journal article (peer-reviewed)abstract
    • Human recombinant collagen can be cross-linked with a variety of chemical cross-linking agents. Cross-linking methods can be tuned to confer collagen-based scaffolds with specific physical properties, improved antigenicity and thermal stability without impeding the ability of the material to integrate into the surrounding tissue and to promote regeneration. Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. Carbodiimides are referred to as zero-length cross-linking agents as they are not incorporated into the final cross-link and thus pose minimal risk with respect to cytotoxicity. The resulting collagen-based scaffold possesses properties comparable to that of the human cornea and is thus suitable for use as a corneal substitute.
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  • Result 1-2 of 2
Type of publication
journal article (1)
book chapter (1)
Type of content
other academic/artistic (1)
peer-reviewed (1)
Author/Editor
Griffith, May (2)
Lagali, Neil (1)
Merrett, Kimberley (1)
Fagerholm, Per (1)
Islam, Mohammad Mira ... (1)
University
Linköping University (2)
Karolinska Institutet (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Year
2013 (2)

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