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- Ekbom, Barbara, et al.
(author)
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Consumption of flea beetles (Phyllotreta, Coleoptera: Chrysomelidae) by spiders in field habitats detected by molecular analysis
- 2014
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In: Canadian Entomologist. - : Cambridge University Press (CUP). - 0008-347X .- 1918-3240. ; 146, s. 639-651
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Journal article (peer-reviewed)abstract
- Flea beetles, Phyllotreta Chevrolat (Coleoptera: Chrysomelidae) species, are often found in oilseed rape (OSR), Brassica napus Linnaeus (Brassicaceae). Among predators in the generalist predator complex present in agricultural fields, wolf spiders (Araneae: Lycosidae) are found on the ground and cobweb spiders (Araneae: Theridiidae) build webs in the foliage. We present group-specific primers developed for five flea beetle species within the genus Phyllotreta and study the incidence of predation of flea beetles by these spider groups using DNA-based gut-content analysis. Wolf spiders of the genus Pardosa Koch and the cobweb spider, Phylloneta impressa (Koch), were collected in three winter OSR fields. Flea beetle densities as well as the occurrence of predators and alternative prey were monitored. In total 19.4% of the collected Pardosa tested positive for flea beetle DNA in the polymerase chain reaction analyses, whereas 10% P. impressa were positive. Pardosa were more likely to be positive for flea beetle DNA when Pardosa activity density was low. Phylloneta impressa were more likely to be positive for flea beetle DNA if they were positive for pollen beetle DNA. Implications of these results for conservation biological control and future studies of food webs in OSR are discussed.
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- Ericson Öberg, Anna, et al.
(author)
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A pull approach to performance measurement systems design
- 2019
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Conference paper (other academic/artistic)abstract
- The literature covering the design of performance measurement systems (PMS) is extensive. Empirically based cases showing how to identify and present the information to support decision-making in the best way is however not as commonly described. The purpose of this article is therefore to close this gap and to propose a novel methodology, the Pull approach, for designing performance measurements. It will provide a description of the Pull approach, position it into context in the literature and exemplify how the methodology could be used by presenting industrial case studies.
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- Grövdal, Michael, et al.
(author)
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Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome
- 2007
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 13:23, s. 7107-7112
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Journal article (peer-reviewed)abstract
- PURPOSE: Promoter hypermethylation of, for example, tumor-suppressor genes, is considered to be an important step in cancerogenesis and a negative risk factor for survival in patients with myelodysplastic syndromes (MDS); however, its role for response to therapy has not been determined. This study was designed to assess the effect of methylation status on the outcome of conventional induction chemotherapy. EXPERIMENTAL DESIGN: Sixty patients with high-risk MDS or acute myeloid leukemia following MDS were treated with standard doses of daunorubicin and 1-beta-d-arabinofuranosylcytosine. Standard prognostic variables and methylation status of the P15(ink4b) (P15), E-cadherin (CDH), and hypermethylated in cancer 1 (HIC) genes were analyzed before treatment. RESULTS: Forty percent of the patients achieved complete remission (CR). CR rate was lower in patients with high WBC counts (P = 0.03) and high CD34 expression on bone marrow cells (P = 0.02). Whereas P15 status alone was not significantly associated with CR rate (P = 0.25), no patient with hypermethylation of all three genes achieved CR (P = 0.03). Moreover, patients with CDH methylation showed a significantly lower CR rate (P = 0.008), and CDH methylation retained its prognostic value also in the multivariate analysis. Hypermethylation was associated with increased CD34 expression, but not with other known predictive factors for response, such as cytogenetic profile. CONCLUSIONS: We show for the first time a significant effect of methylation status on the outcome of conventional chemotherapy in high-risk MDS and acute myelogenous leukemia following MDS. Provided confirmed in an independent study, our results should be used as a basis for therapeutic decision-making in this patient group.
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- Hinkula, Jorma, et al.
(author)
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Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells
- 2009
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In: VACCINE. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 27:46, s. 6424-6431
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Journal article (peer-reviewed)abstract
- Dendritic cells present microbial antigens to T cells after uptake of apoptotic vesicles from infected cells. We previously reported that immunizations with apoptotic HIV-1/murine leukemia virus (MuLV) infected cells lead to induction of both cellular and humoral immune responses as well as resistance to mucosal challenge with live HIV-1/MuLV infected cells. Here we extended those studies and investigated whether apoptotic cells from HIV-1/MuLV infected cells stimulate the production of HIV-1 neutralizing activity. We compared different routes of administration and were able to induce p24- and Nef-specific cellular proliferation after intraperitoneal (i.p.), intranasal (i.n.), subcutaneous (s.c.) and intramuscular (i.m.) immunizations. Serum IgG and IgA antibodies directed against gp160, p24, or Nef were also produced regardless of immunization route used. However, the induction of mucosa-associated IgAs from faeces or vaginal secretions were detected only after either i.p. or i.n. immunizations. We were able to measure neutralizing activity in sera of mice after i.p. and i.n. immunization. Neutralizing reactivity was also detected after s.c. and i.m. immunizations in the presence of the cytokine adjuvant granulocyte macrophage-colony stimulating factor (GM-CSF). Conclusively we show induction of cellular and humoral immune responses including neutralizing activity after immunization with apoptotic HIV-1/MuLV infected cells in mice. The results from this study support further evaluations using apoptotic cells as antigen delivery system for vaccination against HIV-1 in other animal models.
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| 7. |
- Kurdve, Martin, 1971, et al.
(author)
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Implementation of daily visual management at five small and medium sized enterprises in Produktionslyftet compared to six larger Swedish companies
- 2016
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In: Swedish Production Symposium 2016.
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Conference paper (peer-reviewed)abstract
- This paper compares the implementation of daily visual management (DVM) in five SMEs (small and medium sized enterprises), with practice in six large Swedish companies, considering the challenge to include sustainability aspects. With method definition from Produktionslyftet (PL), a Swedish development programme, DVM includes daily meetings around key performance indices (KPIs) and visualised information on boards. The SMEs were studied within PL while the large companies were studied in the research project SuReBPMS (Sustainable and resource efficient Business Performance Measurement Systems). The empirical result from SMEs shows that KPIs often cover few areas (most common: delivery, safety and quality) while the larger companies have wider range of areas. In some SMEs the meeting agendas, KPIs and pulse-boards are standardised while in others there are differences between teams or operations. The larger companies were mainly standardised. Both SMEs and larger companies mostly include all employees in DVM, in line with PL-DVM methodology. The general tendency is to focus on short term rather than follow-up of strategic challenges in the DVM. Furthermore, environmental issues, such as climate impact, are rarely found on boards, while often reflected in company policy. However, many KPIs have a strong, indirect, connection to sustainability and environment.
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- Landström, Anna, 1990, et al.
(author)
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A life cycle approach to business performance measurement systems
- 2018
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In: Procedia Manufacturing. - : Elsevier BV. - 2351-9789. ; 25, s. 126-133, s. 126-133
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Conference paper (peer-reviewed)abstract
- Virtually every company has implemented a Business Performance Measurement System (BPMS) with the purpose of monitoring production and business performance and to execute the corporate strategy at all levels in a company. The purpose of this article is to shed light on common pitfalls related to the practical use of BPMS and further to present a life cycle model with the purpose of introducing structured approach to avoiding the pitfalls. The article contributes to further development of the BPMS life cycle concept and practical examples of how it can be used.
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| 9. |
- Landström, Anna, 1990, et al.
(author)
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Present state analysis of BPMS in large manufacturing companies
- 2016
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In: Proceedings from PMA 2016, 10th conference of the Performance Measurement Association 26-29 June 2016 Edinburgh, Scotland.
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Conference paper (peer-reviewed)abstract
- The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturingcompanies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what ismeasured.
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| 10. |
- Landström, Anna, et al.
(author)
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Present state analysis of business performance measurement systems in large manufacturing companies
- 2016
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In: PMA Conference 2016 PMA2016. - Edinburgh, United Kingdom. ; , s. 26-29
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Conference paper (peer-reviewed)abstract
- The purpose of this article is to empirically investigate the present state of the performance measurement systems (PMS) at 7 sites of 6 different large Swedish manufacturing companies. The methodology has both a bottom-up and a top-down perspective. Important findings are that the PMSs are very similar in how they function but differ a lot in what is measured.
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