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1.	Ringden, O, et al. (author) Improved survival after allogeneic haematopoietic stem cell transplantation in recent years 2011 In: BONE MARROW TRANSPLANTATION. - 0268-3369. ; 46, s. S167-S168 Conference paper (other academic/artistic)
2.	Krifors, A, et al. (author) PCR with electrospray ionization-mass spectrometry on bronchoalveolar lavage for detection of invasive mold infections in hematological patients 2019 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 14:2, s. e0212812- Journal article (peer-reviewed)
3.	ACKEFORS, M, et al. (author) GAD65 AUTOANTIBODIES AND ICA DURING NONDIABETIC PREGNANCY PRECEDE IDDM BUT DOES NOT INCREASE RISK IN OFFSPRING 1995 In: DIABETOLOGIA. - 0012-186X. ; 38, s. A70-A70 Conference paper (other academic/artistic)
4.	Ivarsson, SA, et al. (author) Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring 1997 In: Autoimmunity. - : Informa UK Limited. - 0891-6934 .- 1607-842X. ; 26:4, s. 261-269 Journal article (peer-reviewed)
5.	Ackefors, M, et al. (author) Concentration-guided ribavirin dosing with darbepoetin support and peg-IFN alfa-2a for treatment of hepatitis C recurrence after liver transplantation 2012 In: Journal of viral hepatitis. - : Wiley. - 1365-2893 .- 1352-0504. ; 19:9, s. 635-639 Journal article (peer-reviewed)
6.	Ackefors, M, et al. (author) Evolution of fibrosis during HCV recurrence after liver transplantation--influence of IL-28B SNP and response to peg-IFN and ribavirin treatment 2013 In: Journal of viral hepatitis. - : Wiley. - 1365-2893 .- 1352-0504. ; 20:11, s. 770-778 Journal article (peer-reviewed)
7.	Ackefors, M., et al. (author) Peg-IFN and ribavirin treatment for recurrence of genotype 2 and 3 hepatitis C after liver transplantation 2015 In: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 47:4, s. 209-217 Journal article (peer-reviewed)abstract Background: Relapse of hepatitis C virus (HCV) infection after liver transplantation (LT) is universal. Tolerance for treatment with pegylated-interferon (peg-IFN) and ribavirin (RBV) is suboptimal and withdrawals due to adverse events frequent. We sought to improve tolerance for treatment to improve outcome. Methods: We used concentration-guided RBV dosing to achieve an intended 10 mu mol/L concentration with darbepoetin support in combination with peg-IFN alfa-2a, 180 mu g for genotype 1 and 135 mu g for genotype 2/3 to improve tolerance. Results: A total of 51/54 patients (94%) completed a full treatment course. In the per-protocol analysis 43% of patients (22/51) achieved sustained virological response (SVR), 82% with HCV genotype 2/3 and 22% with genotype 1, p = 0.0001. Patients with IL28B CC achieved SVR in 73% (8/11) and patients with non-CC in 33% (14/43), p = 0.016. Patients with mild fi brosis (fi brosis stage 1-2) achieved SVR in 56% (15/27), and patients with advanced fi brosis (fi brosis stage 3 -4) in only 26% (7/27), p = 0.0267. Conclusions: Concentration-guided RBV dosing with darbepoetin support substantially improves tolerance and offers high adherence to a full peg-IFN and RBV treatment course in patients with post-transplant HCV relapse. With this approach genotype 2 and 3 infections can be treated cost-effectively post-transplant. Genotype 1, IL28B non-CC genotype, and advanced fi brosis predicted a low SVR rate.

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Type of publication: journal article (5); conference paper (2)

Type of content: peer-reviewed (5); other academic/artistic (2)

Author/Editor: Ackefors, M (7); Wernerson, A (4); Gjertsen, H (3); Weiland, O (3); Kockum, I. (2); IVARSSON, SA (2); show more...; CARLSSON, A (2); EKBERG, G (2); FALORNI, A (2); LERNMARK, A (2); LINDBERG, B (2); SUNDKVIST, G (2); SVANBERG, L (2); Blennow, O (2); Sonnerborg, A (1); Hassan, M (1); Hassan, Z. (1); Castedal, Maria, 196 ... (1); Olsson, R (1); Marschall, HU (1); Nystrom, J (1); LANDINOLSSON, M (1); Dahlgard, O. (1); Verbaan, Hans (1); Ljungman, P (1); Watz, E. (1); Remberger, M. (1); Mattsson, J. (1); Uhlin, M. (1); Ringden, O (1); Omazic, B (1); Hagglund, H (1); Dahllof, G (1); Wikman, A (1); Klingspor, L (1); Winiarski, J (1); Karlsson, H (1); Gustafsson, B (1); Landin-Olsson, M (1); Wikstrom, AC (1); Berglund, S. (1); Ozenci, V (1); Le Blanc, K (1); Schaffer, M (1); Hauzenberger, D (1); Stralin, K (1); Ullberg, M (1); Svahn, BM (1); Machaczka, M (1); Kumlien, G (1); show less...

University: Karolinska Institutet (7); University of Gothenburg (1); Lund University (1)

Language: English (7)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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