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- 2019
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Journal article (peer-reviewed)
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| 2. |
- Abercrombie, Daniel, et al.
(author)
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Dark Matter benchmark models for early LHC Run-2 Searches : Report of the ATLAS/CMS Dark Matter Forum
- 2020
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In: Physics of the Dark Universe. - : Elsevier BV. - 2212-6864. ; 27
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Journal article (peer-reviewed)abstract
- This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations.
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| 3. |
- Choin, Jeremy, et al.
(author)
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Genomic insights into population history and biological adaptation in Oceania
- 2021
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In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 592:7855, s. 583-589
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Journal article (peer-reviewed)abstract
- The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes(1). However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors of Papuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000 years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000 years ago(2-4). Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes (for example, metabolism, pigmentation and neuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.
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| 4. |
- Kamanzi, Albert, et al.
(author)
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Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles
- 2021
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In: ACS Nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 15:12, s. 19244-19255
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Journal article (peer-reviewed)abstract
- Nanoparticles are a promising solution for delivery of a wide range of medicines and vaccines. Optimizing their design depends on being able to resolve, understand, and predict biophysical and therapeutic properties, as a function of design parameters. While existing tools have made great progress, gaps in understanding remain because of the inability to make detailed measurements of multiple correlated properties. Typically, an average measurement is made across a heterogeneous population, obscuring potentially important information. In this work, we develop and apply a method for characterizing nanoparticles with single-particle resolution. We use convex lens-induced confinement (CLiC) microscopy to isolate and quantify the diffusive trajectories and fluorescent intensities of individual nanoparticles trapped in microwells for long times. First, we benchmark detailed measurements of fluorescent polystyrene nanoparticles against prior data to validate our approach. Second, we apply our method to investigate the size and loading properties of lipid nanoparticle (LNP) vehicles containing silencing RNA (siRNA), as a function of lipid formulation, solution pH, and drug-loading. By taking a comprehensive look at the correlation between the intensity and size measurements, we gain insights into LNP structure and how the siRNA is distributed in the LNP. Beyond introducing an analytic for size and loading, this work allows for future studies of dynamics with single-particle resolution, such as LNP fusion and drug-release kinetics. The prime contribution of this work is to better understand the connections between microscopic and macroscopic properties of drug-delivery vehicles, enabling and accelerating their discovery and development.
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| 5. |
- Leppäkangas, Juha, 1979, et al.
(author)
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Multiplying and detecting propagating microwave photons using inelastic Cooper-pair tunneling
- 2018
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In: Physical Review A. - 2469-9934 .- 2469-9926. ; 97:1
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Journal article (peer-reviewed)abstract
- The interaction between propagating microwave fields and Cooper-pair tunneling across a DC-voltage-biased Josephson junction can be highly nonlinear. We show theoretically that this nonlinearity can be used to convert an incoming single microwave photon into an outgoing n-photon Fock state in a different mode. In this process, the electrostatic energy released in a Cooper-pair tunneling event is transferred to the outgoing Fock state, providing energy gain. The created multiphoton Fock state is frequency entangled and highly bunched. The conversion can be made reflectionless (impedance matched) so that all incoming photons are converted to n-photon states. With realistic parameters, multiplication ratios n > 2 can be reached. By two consecutive multiplications, the outgoing Fock-state number can get sufficiently large to accurately discriminate it from vacuum with linear postamplification and power measurement. Therefore, this amplification scheme can be used as a single-photon detector without dead time.
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