| 1. |
- Aldrich, Howard E., et al.
(author)
-
Entrepreneurship in family firms : What's next? Multilevel embeddedness and individuals’ cognition
- 2023
-
In: The Journal of Family Business Strategy. - : Elsevier. - 1877-8585 .- 1877-8593. ; 14:3
-
Journal article (peer-reviewed)abstract
- This special issue contributes to the literature on entrepreneurship in family firms by leveraging the family embeddedness perspective. In doing so, the papers of the special issue bridge entrepreneurship at firm level with analyses at the individual and the enterprising family levels. Starting from and extending such contributions, in this introductory article we offer a “multilevel” embeddedness perspective on entrepreneurship in family firms. We do so first by considering that, in family firms, each individual's cognition ultimately depends on whether they belong to the enterprising family, and whether and how they are active in the family business. Second, we advance that individual entrepreneurial orientation is a key cognitive factor resulting from the multilevel embeddedness and bridging it with entrepreneurship at firm level. We derive theoretical implications for entrepreneurship in family business and highlight avenues for future research.
|
|
| 2. |
|
|
| 3. |
- Bradley, Steven W., et al.
(author)
-
Resources, environmental change, and survival : Asymmetric paths of young independent and subsidiary organizations
- 2011
-
In: Strategic Management Journal. - : John Wiley & Sons. - 0143-2095 .- 1097-0266. ; 32:5, s. 486-509
-
Journal article (peer-reviewed)abstract
- Using an evolutionary model and a sample of 7,166 firms in the manufacturing and technology sectors of Sweden, we find that surviving organizations founded independent of a parent organization have lower long-term failure rates than their protected subsidiary counterparts. Specifically, we find that subsidiary organizations have low mortality rates when compared to independent organizations, but that their mortality rates increase more rapidly during a severe economic downturn. We also find evidence that surviving independent organizations are more capable than subsidiary organizations of using their resources to reduce mortality rates during an environmental jolt. Overall, our findings strengthen the notion that organizational adaptation is linked not only to ecological and strategic processes but also to organizational structure.
|
|
| 4. |
- Hellerstedt, Karin, 1975-
(author)
-
The Composition of New Venture Teams : Its Dynamics and Consequences
- 2009
-
Doctoral thesis (other academic/artistic)abstract
- New venture team composition lies at the heart of this thesis. Drawing on social-psychological explanations and human capital reasoning, the thesis addresses the social as well as the instrumental foci facing new venture teams. This is done by addressing four research questions: 1) What are the characteristics of new venture teams and their team members? 2) What impact does team composition and firm performance have on team dynamics? 3) What impact does team member characteristics and individual deviation have on individual dynamics? 4) How does team composition and team dynamics influence firm performance? Dynamics is studied by investigating the adding and dropping of team members.Research on entrepreneurial teams is characterized by several methodological challenges that this thesis takes on. First, there is a lack of longitudinal studies. Second, no studies are based on truly random samples of teams. Third, the unit and level of analysis has been the team and the firm. Rarely is the individual considered. In addition, the thesis sheds light on team diversity and its effects as well as the relationship with performance, both as an antecedent and as a consequence.The empirical setting is based on a unique database covering all individuals entering into self-employment in knowledge-intensive industries in Sweden during the 1996 to 2000 period. Their firms are tracked annually up to 2002, providing a census panel three to seven years long consisting of five cohorts. This is done by using secondary data from Statistics Sweden (SCB) covering information on individuals as well as their firms. By combining individual and firm level data, the thesis demonstrates how team level constructs can be obtained.Overall, the hypothesized relations predicting team member and individual exits receive strong support. Entries to teams and the performance of the firms are not as well explained by the chosen constructs. The findings show that greater internal diversity along some but not all demographic dimensions is positively associated with a higher rate of team member exits. More precisely,when diversity can be linked to status differences, the impact is more pronounced. Furthermore, the findings show that deviation from others in the group has an impact on which individual is likely to leave the team. There are also considerable differences in behavior between teams consisting of spousal pairs and other teams. In fact, the findings show that spousal couples venturing together are very common and that the typical team does not match the entrepreneurial team as it often is portrayed in the literature. In sum, the study suggests that diversity in attributes related to status can influence team stability. In addition, trust and prior relationships appear to be especially important for the creation and development of new venture teams.
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Jacobs, Kevin B, et al.
(author)
-
Detectable clonal mosaicism and its relationship to aging and cancer.
- 2012
-
In: Nature Genetics. - New York : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 44:6, s. 651-658
-
Journal article (peer-reviewed)abstract
- In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.
|
|
| 8. |
- Machiela, Mitchell J., et al.
(author)
-
Characterization of Large Structural Genetic Mosaicism in Human Autosomes
- 2015
-
In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 96:3, s. 487-497
-
Journal article (peer-reviewed)abstract
- Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 x 3 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
|
|
| 9. |
- Robbins, Hilary A., et al.
(author)
-
Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program
- 2023
-
In: Annals of Epidemiology. - : Elsevier. - 1047-2797 .- 1873-2585. ; 77, s. 1-12
-
Journal article (peer-reviewed)abstract
- The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies.
|
|
| 10. |
- Wang, Zhaoming, et al.
(author)
-
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
- 2014
-
In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
-
Journal article (peer-reviewed)abstract
- Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
|
|
