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Träfflista för sökning "WFRF:(Allison James R.) "

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Enumeration	Reference	Cover	Find
1.	2021 swepub:Mat__t
2.	Bravo, L, et al. (author) 2021 swepub:Mat__t
3.	Tabiri, S, et al. (author) 2021 swepub:Mat__t
4.	2021 swepub:Mat__t
5.	Glasbey, JC, et al. (author) 2021 swepub:Mat__t
6.	Ahmad, T, et al. (author) Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries 2016 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 117:5, s. 601- Journal article (peer-reviewed)
7.	Ahmad, T, et al. (author) In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study 2017 In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 43:12, s. 2324-2332 Journal article (peer-reviewed)
8.	Ahmad, T, et al. (author) Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery 2017 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 119:2, s. 258-266 Journal article (peer-reviewed)
9.	2019 Journal article (peer-reviewed)
10.	Turcot, Valerie, et al. (author) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity 2018 In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41 Journal article (peer-reviewed)abstract Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.

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Result 1-10 of 58

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Type of publication: journal article (50); research review (2); conference paper (1)

Type of content: peer-reviewed (53)

Author/Editor: Rotter, Jerome I. (10); Lind, Lars (9); Martin, J. (8); Patel, P. (8); Miller, D. (8); Ali, M (8); show more...; Ali, S (8); Singh, A (8); Shah, S (8); Brown, L. (8); Pata, F (8); Mutter, D (8); Smith, C (8); Minto, G (8); Tayeh, S (8); Patel, K (8); Harries, R (8); Patel, M (8); Thomas, A (8); Wareham, Nicholas J. (8); Dunning, Alison M. (8); Easton, Douglas F. (8); Ikram, M. Arfan (8); van Duijn, Cornelia ... (8); Mohlke, Karen L (8); Thomas, M (8); Bello, J (8); Raptis, DA (8); Jones, D (8); Shah, K (8); Allison, J (8); Zhang, H. (7); Brown, A. (7); Salomaa, Veikko (7); Allison, Matthew (7); Edwards, J (7); Alameer, E (7); Ahmed, A (7); Fowler, A (7); Auer, Paul L. (7); Jones, C (7); Ridker, Paul M. (7); Chasman, Daniel I. (7); Langenberg, Claudia (7); Boehnke, Michael (7); Scott, Robert A (7); Abbott, T (7); Vohra, R (7); Mahajan, Anubha (7); Luan, Jian'an (7); show less...

University: Uppsala University (25); Karolinska Institutet (19); Umeå University (14); Lund University (14); University of Gothenburg (10); Stockholm University (10); show more...; Royal Institute of Technology (3); Chalmers University of Technology (3); Linköping University (2); Swedish University of Agricultural Sciences (2); Luleå University of Technology (1); Halmstad University (1); Stockholm School of Economics (1); Mid Sweden University (1); Södertörn University (1); RISE (1); Swedish Museum of Natural History (1); show less...

Language: English (58)

Research subject (UKÄ/SCB): Medical and Health Sciences (27); Natural sciences (26); Social Sciences (2); Engineering and Technology (1); Agricultural Sciences (1); Humanities (1)

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