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| 2. |
- Andersson, Magnus, et al.
(författare)
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Fiskbestånd och miljö i hav och sötvatten : Resurs- och miljööversikt 2012
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Detta är den nionde utgåvan av den samlade översikten över fisk- och kräftdjursbeståndens status i våra vatten. Kunskap om fiskbestånden och miljön är en förutsättning för att utnyttjandet av fiskresurserna skall bli bärkraftigt. För svenska vattenområden beskrivs miljöutvecklingen i ett ekosystemsperspektiv, dels för att tydliggöra fiskens ekologiska roll och beskriva yttre miljöfaktorer som påverkar fiskbestånden, dels för att belysa fiskets effekter på miljön.Fiskbestånd och miljö i hav och sötvatten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten. Rapporten sammanfattar utveckling och beståndsstatus för de kommersiellt viktigaste fisk- och kräftdjursarterna i våra vatten. Bedömningar och förvaltningsråd är baserade på Internationella Havsforskningsrådets (ICES) rådgivning, SLU Aquas nationella och regionala provfiskedata, samt yrkesfiskets rapportering.
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| 3. |
- Alipour, Mohammad, et al.
(författare)
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A surrogate-assisted uncertainty quantification and sensitivity analysis on a coupled electrochemical–thermal battery aging model
- 2023
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Ingår i: Journal of Power Sources. - : Elsevier BV. - 0378-7753 .- 1873-2755. ; 579
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Tidskriftsartikel (refereegranskat)abstract
- High-fidelity physics-based models are required to comprehend battery behavior at various operating conditions. This paper proposes an uncertainty quantification analysis on a coupled electrochemical–thermal aging model to improve the reliability of a battery model, while also investigating the impact of parametric model uncertainties on battery voltage, temperature, and aging. The coupled model's high computing cost, however, is a significant barrier to perform uncertainty quantification (UQ) and sensitivity analysis (SA). To address this problem, a surrogate model – i.e, by simulating the outcome of a quantity of interest that cannot be easily computed or measured – based on the Gaussian process regression (GPR) theory and principle component analysis (PCA) is built, using a small collection of finite element simulation results as synthetic training data. In total, 43 variable electrochemical–thermal parameters as well as 13 variable aging parameters are studied and estimated. Moreover, the trained surrogate model is also used in the parameterization of the electrochemical and thermal models. The results show that the uncertainties in the input parameters significantly affect the estimations of battery voltage, temperature, and aging. Based on this sensitivity analysis, the most influential parameters affecting the above mentioned battery outputs are reported. This approach is thereby helpful for developing robust and reliable high-fidelity battery aging models with potential applications in digital twins as well as for synthetic data generation.
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| 4. |
- Andersson, Jan, et al.
(författare)
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Fisk- och skaldjursbestånd i hav och sötvatten 2015 : Resursöversikt
- 2015
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I rapporten kan du ta del av bedömningen som görs av situationen för bestånd som regleras inom ramen för EU:s gemensamma fiskeripolitik (GFP). Bedömningarna baseras på det forskningssamarbete och den rådgivning som sker inom det Internationella Havsforskningsrådet (ICES).De bestånd som förvaltas nationellt baseras på de biologiska underlagen och rådgivningen i huvudsak på den forskning och övervakning samt analys som bedrivs av Institutionen för akvatiska resurser (SLU Aqua) vid Sveriges lantbruksuniversitet (SLU) samt yrkesfiskets rapportering.Rapporten omfattar 40 fiskarter uppdelade i olika bestånd, samt sex skal-och blötdjursarter.Nytt för årets upplaga är en beskrivning av hur de provfisken som ligger till grund för analys och rådgivning utförs.Översikten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten.
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| 5. |
- Havervall, Sebastian, et al.
(författare)
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SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
- 2022
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 17:1, s. e0262169-e0262169
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Tidskriftsartikel (refereegranskat)abstract
- Current SARS-CoV-2 serological assays generate discrepant results, and the longitudinal characteristics of antibodies targeting various antigens after asymptomatic to mild COVID-19 are yet to be established. This longitudinal cohort study including 1965 healthcare workers, of which 381 participants exhibited antibodies against the SARS-CoV-2 spike antigen at study inclusion, reveal that these antibodies remain detectable in most participants, 96%, at least four months post infection, despite having had no or mild symptoms. Virus neutralization capacity was confirmed by microneutralization assay in 91% of study participants at least four months post infection. Contrary to antibodies targeting the spike protein, antibodies against the nucleocapsid protein were only detected in 80% of previously anti-nucleocapsid IgG positive healthcare workers. Both anti-spike and anti-nucleocapsid IgG levels were significantly higher in previously hospitalized COVID-19 patients four months post infection than in healthcare workers four months post infection (p = 2*10−23 and 2*10−13 respectively). Although the magnitude of humoral response was associated with disease severity, our findings support a durable and functional humoral response after SARS-CoV-2 infection even after no or mild symptoms. We further demonstrate differences in antibody kinetics depending on the antigen, arguing against the use of the nucleocapsid protein as target antigen in population-based SARS-CoV-2 serological surveys
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| 6. |
- Heinonen, Essi, et al.
(författare)
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MAGDALENA : study protocol of a randomised, placebo-controlled trial on cognitive development at 2 years of age in children exposed to SSRI in utero
- 2018
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Ingår i: BMJ Open. - : BMJ Publishing Group Ltd. - 2044-6055. ; 8:8
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Tidskriftsartikel (refereegranskat)abstract
- Introduction Ten per cent of all pregnant women are depressed. Standard therapy of pregnant women with moderate depression is selective serotonin reuptakeinhibitors (SSRI). Observational studies on neurodevelopment after fetal SSRI exposure show conflicting results. Our primary objective is to compare the cognitive development in children exposed to sertraline and maternal depression with those exposed to maternal depression and placebo in utero. We hypothesise that there is a significant neurodevelopmental difference between the groups. As a secondary objective, we study the add-on effect of sertraline to internet-based cognitive behavioural therapy (ICBT) to treat moderate depression during pregnancy. Methods and analysis MAGDALENA is a randomised, placebo-controlled, double-blinded trial in Stockholm Healthcare Region with 2.3 million inhabitants. The women are recruited in weeks 9-21 of pregnancy either through Antenatal Health Clinics or through social media. They are to be diagnosed with moderate depression without ongoing antidepressive therapy or any serious comorbidity. The women in the intervention arm receive sertraline combined with a 12-week period of ICBT; the control arm is treated with placebo and ICBT. We assess the cognitive development in the offspring at the age of 2 years using Bayley Scales of Infant and Toddler Development, third edition (BSID-III). We aim at recruiting 200 women, 100 women in each treatment arm, to ensure statistical power to detect a clinically relevant difference between the groups. Ethics and dissemination This randomised trial will provide long-sought evidence about the effects of SSRI and maternal depression during pregnancy on the neurodevelopment in the offspring. The study is approved by the Regional Ethical Review Board at Karolinska Institutet in Stockholm and the Swedish Medical Products Agency. It is registered with the European Clinical Trials Database (EudraCT), Number: 2013-004444-31. Results will be disseminated at scientific conferences, published in peer-reviewed journals and made available to the public.
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| 7. |
- Lee, Kian Keat, et al.
(författare)
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Tailored activated carbons for supercapacitors derived from hydrothermally carbonized sugars by chemical activation
- 2016
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 6:112, s. 110629-110641
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Tidskriftsartikel (refereegranskat)abstract
- Activated carbons (ACs) are actively researched as electrode materials for supercapacitors and there is a significant interest to produce ACs from sustainable and low cost precursors. In this study, various ACs were prepared from hydrothermally carbonized sugars by KOH activation. Both the hydrothermal carbonization and activation processes were optimized to tailor the properties (e.g. textural properties, chemical composition, N-doping, electrical conductivity) of the ACs. For instance, the Brunauer-Emmett-Teller (BET) surface areas (S-BET) were tuned in the range of 800-3000 m(2) g(-1) with associated variation in the extent of microporosity and pore size distributions (PSDs). The ACs were evaluated electrochemically as materials for supercapacitor electrodes in a symmetrical two-electrode cell using an aqueous electrolyte. The relationship between the electrochemical, textural, electrical, and physicochemical properties were analyzed systematically to understand the key factors determining the electrochemical performance. A high specific capacitance (C-m) of similar to 260 F g(-1) was achieved at a moderately high S-BET of similar to 1300 m(2) g(-1), which was equivalent to a C-m/S-BET of 20 mu F cm(-2), for an optimal AC prepared from hydrothermally carbonized glucose. The very high surface-specific capacitance highlights that the specific surface area is certainly not the sole limiting parameter for effective electrode materials.
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| 8. |
- Nygren, Kristian, et al.
(författare)
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Passive films on nanocomposite carbide coatings for electrical contact applications
- 2017
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Ingår i: Journal of Materials Science. - : SPRINGER. - 0022-2461 .- 1573-4803. ; 52:13, s. 8231-8246
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Tidskriftsartikel (refereegranskat)abstract
- Nanocomposite transition metal carbide/amorphous carbon coatings (Me-C/a-C) deposited by magnetron sputtering have excellent electrical contact properties. The contact resistance can be as low as that of noble metal coatings, although it is known to vary by several orders of magnitude depending on the deposition conditions. We have investigated a nanocrystalline niobium carbide/amorphous carbon (NbC (x) /a-C:H) model system aiming to clarify factors affecting the contact resistance for this group of contact materials. For the first time, the surface chemistry is systematically studied, by angle-resolved X-ray photoelectron spectroscopy, and in extension how it can explain the contact resistance. The coatings presented a mean oxide thickness of about 1 nm, which could be grown to 8 nm by annealing. Remarkably, the contact resistances covered four orders of magnitude and were found to be exponentially dependent on the mean oxide thickness. Moreover, there is an optimum in the amount of a-C:H phase where the contact resistance drops very significantly and it is thus important to not only consider the mean oxide thickness. To explain the results, a model relying on surface chemistry and contact mechanics is presented. The lowest contact resistance of a nanocomposite matched that of a gold coating at 1 N load (vs. gold), and such performance has previously not been demonstrated for similar nanocomposite materials, highlighting their useful properties for electrical contact applications.
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| 9. |
- Wikman, Maria, et al.
(författare)
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Achieving directed immunostimulating complex incorporation
- 2006
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Ingår i: Expert Review of Vaccines. - : Informa UK Limited. - 1476-0584 .- 1744-8395. ; 5:3, s. 395-403
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Forskningsöversikt (refereegranskat)abstract
- In recent years, several studies have been reported with the common aim of generating general expression systems for straightforward production and subsequent coupling of expressed antigens to an adjuvant system. Here, we describe a series of such efforts with a common theme of using gene fusion technology for association of recombinant antigens to immunostimulating complexes (iscoms). In the early stages of vaccine development, uniform antigen preparations are crucial to allow the comparison of immune responses to different antigens, or even subdomains thereof, and we believe that the described systems constitute an important development in this context.
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