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| 2. |
- Andersson, Jennie, et al.
(author)
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Design as Information : How May Design and Information Relate?
- 2009
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In: Design Principles and Practices. - : Common Ground Publishing. - 1833-1874. ; 3:4, s. 161-172
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Journal article (peer-reviewed)abstract
- According to Pettersson, design may be a process and/or the result of the process, a product. The area of design is multidisciplinary and involves several notions. One is in the subject field of Information Design, which includes language, communication, art, cognition and information science. These disciplines refer to the concept of information differently. There is therefore a need for a fruitful theory of information, terms and concepts in order to enrich the reasoning of design as information. Bates presents a definition of information and several fundamental information forms. There, she offers a theoretical framework, the main core of which is that information may take different forms related to architecture, graphic design, interior design, and interface design, etc. Such a framework may contribute to understanding the meaning of design. Bates’ theory is applied in a study involving spatial design in industrial environments. The conclusions of the study illustrates how design and information relate to a design process and a design product that enriches the understanding of the meaning of design.
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| 3. |
- Andersson, Jennie, 1978, et al.
(author)
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Eosinophils from hematopoietic stem cell recipients suppress allogeneic T cell proliferation.
- 2014
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In: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. - : Elsevier BV. - 1523-6536. ; 20:12, s. 1891-8
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Journal article (peer-reviewed)abstract
- Eosinophilia has been associated with less severe graft-versus-host disease (GVHD), but the underlying mechanism is unknown. We hypothesized that eosinophils diminish allogeneic T cell activation in patients with chronic GVHD. The capacity of eosinophils derived from healthy subjects and hematopoietic stem cell (HSC) transplant recipients, with or without chronic GVHD, to reduce allogeneic T cell proliferation was evaluated using a mixed leukocyte reaction. Eosinophil-mediated inhibition of proliferation was observed for the eosinophils of both healthy subjects and patients who underwent HSC transplantation. Eosinophils from patients with and without chronic GVHD were equally suppressive. Healthy eosinophils required cell-to-cell contact for their suppressive capacity, which was directed against CD4(+) T cells and CD8(+) T cells. Neither eosinophilic cationic protein, eosinophil-derived neurotoxin, indoleamine 2,3-dioxygenase, or increased numbers of regulatory T cells could account for the suppressive effect of healthy eosinophils. Real-time quantitative PCR analysis revealed significantly increased mRNA levels of the immunoregulatory protein galectin-10 in the eosinophils of both chronic GVHD patients and patients without GVHD, as compared with those from healthy subjects. The upregulation of galectin-10 expression in eosinophils from patients suggests a stimulatory effect of HSC transplantation in itself on eosinophilic galectin-10 expression, regardless of chronic GVHD status. To conclude, eosinophils from HSC transplant recipients and healthy subjects have a T cell suppressive capacity.
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| 4. |
- Lingblom, Christine, 1984, et al.
(author)
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Regulatory Eosinophils Suppress T Cells Partly through Galectin-10
- 2017
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In: Journal of Immunology. - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 198:12, s. 4672-4681
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Journal article (peer-reviewed)abstract
- Eosinophils have the capacity to regulate the function of T cell subsets. Our aim was to test the hypothesis of the existence of a regulatory subset of eosinophils. Human eosinophils were incubated with T cells that were stimulated with allogeneic leukocytes or CD3/ CD28 cross-linking. After 2 d of coculture, 11% of the eosinophils gained CD16 expression. A CD16(hi) subset of eosinophils, encompassing 1-5% of all eosinophils, was also identified in the blood of healthy subjects. FACS sorting showed that these CD16(hi) eosinophils were significantly stronger suppressors of T cell proliferation than were conventional CD16 neg eosinophils. Human eosinophils contain stores of the immunoregulatory protein galectin-10. We found that Ab-mediated neutralization of galectin-10 partially abrogated the suppressive function of the eosinophils. Moreover, recombinant galectin-10 by itself was able to suppress T cell proliferation. Finally, we detected galectin-10-containing immune synapses between eosinophils and lymphocytes. To conclude, we describe a subset of suppressive eosinophils expressing CD16 that may escape detection because CD16-based negative selection is the standard procedure for the isolation of human eosinophils. Moreover, we show that galectin-10 functions as a T cell-suppressive molecule in eosinophils.
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| 5. |
- Ablikim, M., et al.
(author)
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Measurement of e (+) e (-) -> gamma chi(c0,c1,c2) cross sections at center-of-mass energies between 3.77 and 4.60 GeV
- 2021
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In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 104:9
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Journal article (peer-reviewed)abstract
- BESIII detector at BEPCII. We observe for the first time e(+)e(-)->gamma chi(c1; c2) signals at root s = 4.180 GeV with statistical significances of 7.6s and 6.0s, respectively. The production cross section of e(+)e(-)->gamma chi(c1; c2) at each center-of-mass energy is also measured. We find that the line shape of the e(+)e(-) ->gamma chi(c1) cross section can be described with conventional charmonium states psi(3686), psi(3770), psi(4040), psi(4160). Compared with this, for the e(+)e(-) ->gamma chi(c2) channel, one more additional resonance is added to describe the cross section line shape. Its mass and width are measured to be M = 4371.7 +/- 7.5 +/- 1.8 MeV=c(2) and G(tot) 1/4 =51.1 +/- 17.6 +/- 1.9 MeV, where the first uncertainties are statistical and the second systematic. The significance of this resonance is estimated to be 5.8s, and its parameters agree with the Yo4360THORN resonance previously reported in e(+)e(-)-> pi+pi(-)psi(3686), and the Y(4390) in e(+)e(-). pi(+)pi(-) h(c) within uncertainties. No significant signal for the e(+)e(-->)gamma chi(c0) process is observed, and the upper limits of Born cross sections sigma(B)(e(+)e(-)->gamma chi(c0)) at 90% confidence level are reported.
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| 7. |
- Andersson, Jennie, 1974-
(author)
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Already there? : cultivating emergent places for radical innovation in operations
- 2017
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In: International Series in Operations Research & Management Science, Volume 255. - Cham : Springer New York LLC. - 9783319559841 ; , s. 131-149
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Book chapter (peer-reviewed)abstract
- This chapter proposes a way of understanding and cultivating places for radical innovation in operations. This chapter describes how, organisations can, instead of letting an innovation laboratory be its single economic and managerial priority, foster a decentralised, varied and emergent palette of places in use where radical innovation can occur. The chapter suggests that this can be done in lean production facilities and radical innovation be balanced with incremental innovation.
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| 8. |
- Andersson, Jennie, 1986, et al.
(author)
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CFD Simulations of the Japan Bulk Carrier Test Case
- 2015
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In: NUMERICAL TOWING TANK SYMPOSIUM. 18TH 2015. (NUTTS 2015). - 9781510815858
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Conference paper (peer-reviewed)abstract
- This computational fluid dynamics (CFD) validation study is performed as a foundation for further studies with focus on the interaction effects between propulsor and hull. To be able to study the interaction effects, an appropriate CFD methodology need to be established and validated for a bare hull, for the propulsion unit and for the combined system, a self-propelled hull. The work to validate a CFD model is initiated through the use of the JBC, Japan Bulk Carrier, open test case. The JBC test case is developed for the 2015 workshop on CFD in Ship Hydrodynamics. The tested JBC only exists in model scale with scale factor 1:40 (LPP = 7 m). Model ship speed is 1.179 m/s, corresponding to Fn = 0.142 and 14.5 kn, only calm water conditions are tested. There are two variants of the hull, with and without an energy saving device, within this study the one without is used. Test data used for validation of the CFD results are from towing tank experiments at NMRI. The aim of further studies is to study propulsor hull interaction in full scale, but since detailed test data in full scale is limited, all computations will be performed in model scale. The commercial CFD package STAR-CCM+, a finite volume method solver, is employed for all studies. STAR-CCM+ is a general purpose CFD code used for a wide variety of applications. It solves the conservation equations for momentum and mass, turbulence quantities and volume fraction of water using a segregated solver based on the SIMPLE-algorithm. A 2nd order upwind discretization scheme in space is used. It is of interest to study how a general purpose code can perform for detailed ship hydrodynamic analyses and which limitations that could be identified.
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| 9. |
- Andersson, Jennie, 1978, et al.
(author)
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Effect of 2-hydroxyethyl-methacrylate (HEMA) on the phagocytic and respiratory burst activity of human neutrophils and monocytes.
- 2008
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In: European Journal of Oral Sciences. - : Wiley. - 0909-8836 .- 1600-0722. ; 116:4, s. 369-374
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Journal article (peer-reviewed)abstract
- Neutrophils and monocytes/macrophages (MØ), found in oral mucosa and gingival sulcus, phagocytose and kill bacteria using products produced during a respiratory burst. 2-Hydroxyethyl-methacrylate (HEMA) is a major component released from resin glass ionomer and dental adhesives. Hence, in pulp and gingiva, phagocytes can come into contact with unpolymerized HEMA monomers. The aim of this study was to examine the effects of exposure to HEMA on neutrophil and monocyte bactericidal function. Blood collected from five female volunteers was exposed in vitro to HEMA for 2 h and then phagocytosis, respiratory burst, and cellular integrity were measured using flow cytometry. Respiratory burst was quantified by measuring fluorescent rhodamine 123 generated via oxidation of dihydrorhodamine 123. Cellular membrane integrity was evaluated by staining with propidium iodide. The respiratory burst activity of the neutrophils was significantly decreased by exposure to 7.5 and 15 mM HEMA. No significant effect of HEMA was seen on the number of granulocytes or monocytes capable of performing respiratory burst. Furthermore, there was no significant effect of HEMA on the phagocytic activity of the monocytes or the granulocytes. In conclusion, HEMA did not affect the phagocytosis activity of neutrophils; however, the ability of the cells to kill internalized prey was significantly reduced.
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